MedKoo Cat#: 465555 | Name: ASP8302

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ASP8302 is a novel positive allosteric modulator (PAM) of M3 receptors, enhancing the activation of human M3 receptors by interacting with a single amino acid distinct from the reported allosteric sites.

Chemical Structure

ASP8302
ASP8302
CAS#1839583-42-4

Theoretical Analysis

MedKoo Cat#: 465555

Name: ASP8302

CAS#: 1839583-42-4

Chemical Formula: C26H32ClN7O3S2

Exact Mass: 589.1697

Molecular Weight: 590.16

Elemental Analysis: C, 52.92; H, 5.47; Cl, 6.01; N, 16.61; O, 8.13; S, 10.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
ASP8302; ASP 8302 ASP-8302;
IUPAC/Chemical Name
3-((S)-4-(5-((4-(4-chlorothiophen-2-yl)-5-(((R)-2-methylpyrrolidin-1-yl)methyl)thiazol-2-yl)carbamoyl)pyrazin-2-yl)-2-methylpiperazin-1-yl)propanoic acid
InChi Key
QEVOTPLHYBIHKJ-SJORKVTESA-N
InChi Code
InChI=1S/C26H32ClN7O3S2/c1-16-4-3-6-33(16)14-21-24(20-10-18(27)15-38-20)30-26(39-21)31-25(37)19-11-29-22(12-28-19)34-9-8-32(17(2)13-34)7-5-23(35)36/h10-12,15-17H,3-9,13-14H2,1-2H3,(H,35,36)(H,30,31,37)/t16-,17+/m1/s1
SMILES Code
O=C(O)CCN1[C@@H](C)CN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(CN5[C@H](C)CCC5)S3)=O)N=C2)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 590.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Okimoto R, Ino K, Ishizu K, Takamatsu H, Sakamoto K, Yuyama H, Fuji H, Someya A, Ohtake A, Ishigami T, Masuda N, Takeda M, Kajioka S, Yoshimura N. Potentiation of muscarinic M3 receptor activation through a new allosteric site with anovelpositive allosteric modulator ASP8302. J Pharmacol Exp Ther. 2021 Jul 8:JPET-AR-2021-000709. doi: 10.1124/jpet.121.000709. Epub ahead of print. PMID: 34244231.