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MedKoo Cat#: 574036 | Name: Asperglaucide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Asperglaucide is an amide with anti-inflammatory, antibacterial, antioxidant, and anticancer properties. Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E2 (PGE2), and IL-1β. It is active against Gram-negative bacteria and has antioxidant activity. Asperglaucide decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 µM and reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model.

Chemical Structure

Asperglaucide
Asperglaucide
CAS#56121-42-7

Theoretical Analysis

MedKoo Cat#: 574036

Name: Asperglaucide

CAS#: 56121-42-7

Chemical Formula: C27H28N2O4

Exact Mass: 444.2049

Molecular Weight: 444.53

Elemental Analysis: C, 72.95; H, 6.35; N, 6.30; O, 14.40

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
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Synonym
Asperglaucide, Aurantiamide Acetate
IUPAC/Chemical Name
(S)-2-((S)-2-benzamido-3-phenylpropanamido)-3-phenylpropyl acetate
InChi Key
VZPAURMDJZOGHU-DQEYMECFSA-N
InChi Code
InChI=1S/C27H28N2O4/c1-20(30)33-19-24(17-21-11-5-2-6-12-21)28-27(32)25(18-22-13-7-3-8-14-22)29-26(31)23-15-9-4-10-16-23/h2-16,24-25H,17-19H2,1H3,(H,28,32)(H,29,31)/t24-,25-/m0/s1
SMILES Code
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)COC(C)=O)=O)C3=CC=CC=C3
Appearance
Solid powder
Purity
>70% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PLoS One. 2016 Jun 23;11(6):e0157847. doi: 10.1371/journal.pone.0157847. PMID: 27337135; PMCID: PMC4918958. 12: Ingenbleek L, Sulyok M, Adegboye A, Hossou SE, Koné AZ, Oyedele AD, Kisito CSKJ, Dembélé YK, Eyangoh S, Verger P, Leblanc JC, Le Bizec B, Krska R. Regional Sub-Saharan Africa Total Diet Study in Benin, Cameroon, Mali and Nigeria Reveals the Presence of 164 Mycotoxins and Other Secondary Metabolites in Foods. Toxins (Basel). 2019 Jan 17;11(1):54. doi: 10.3390/toxins11010054. Erratum in: Toxins (Basel). 2019 Feb 28;11(3): PMID: 30658506; PMCID: PMC6356755. 13: Wang H, Gao S, Li J, Ma X, Liu W, Qian S. Hybrids of aurantiamide acetate and isopropylated genipin as potential anti-inflammatory agents: The design, synthesis, and biological evaluation. Chem Biol Drug Des. 2021 Apr;97(4):797-808. doi: 10.1111/cbdd.13809. Epub 2020 Nov 30. PMID: 33219736. 14: Songue JL, Kouam, Dongo E, Mpondo TN, White RL. Chemical constituents from stem bark and roots of Clausena anisata. Molecules. 2012 Nov 20;17(11):13673-86. doi: 10.3390/molecules171113673. PMID: 23169265; PMCID: PMC6268541. 15: Ducki S, Hadfield JA, Zhang X, Lawrence NJ, McGown AT. Isolation of aurantiamide acetate from Arisaema erubescens. Planta Med. 1996 Jun;62(3):277-8. doi: 10.1055/s-2006-957878. PMID: 8693046. 16: Tsai PL, Wang JP, Chang CW, Kuo SC, Chao PD. Constituents and bioactive principles of Polygonum chinensis. Phytochemistry. 1998 Nov;49(6):1663-6. doi: 10.1016/s0031-9422(98)00322-7. PMID: 9862141. 17: Wei L, Chen J, Ye W, Zhou G. [Chemical constituents contained in roots of Pterospermum heterophyllum]. Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1981-4. Chinese. PMID: 23019883. 18: Yen CT, Hwang TL, Wu YC, Hsieh PW. Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. Eur J Med Chem. 2009 May;44(5):1933-40. doi: 10.1016/j.ejmech.2008.11.008. Epub 2008 Nov 27. PMID: 19110343. 19: Liu C, Sun H, Wang WT, Sun JY, Smith MA. 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