MedKoo Cat#: 145775 | Name: Asperenone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Asperenone has been identified as an inhibitor of 15-lipoxygenase, an enzyme involved in the metabolism of arachidonic acid, and has demonstrated platelet aggregation inhibitory activity. The structure of asperenone consists of a conjugated polyene chain with a phenyl group, contributing to its biological activities. Research has shown that asperenone can inhibit human platelet aggregation, which may have implications for cardiovascular health.

Chemical Structure

Asperenone
Asperenone
CAS#18810-05-4

Theoretical Analysis

MedKoo Cat#: 145775

Name: Asperenone

CAS#: 18810-05-4

Chemical Formula: C20H22O

Exact Mass: 278.1700

Molecular Weight: 278.40

Elemental Analysis: C, 86.29; H, 7.97; O, 5.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Asperenone; Asperenon;
IUPAC/Chemical Name
(4E,6E,8E,10E,12E)-8-methyl-13-phenyltrideca-4,6,8,10,12-pentaen-3-one
InChi Key
KMNUJIARVHVQCF-SVCWYOIUSA-N
InChi Code
1S/C20H22O/c1-3-20(21)17-11-10-13-18(2)12-6-4-7-14-19-15-8-5-9-16-19/h4-17H,3H2,1-2H3/b6-4+,13-10+,14-7+,17-11+,18-12+
SMILES Code
CCC(=O)\C=C\C=C\C(C)=C\C=C\C=C\C1=CC=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 278.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chidananda C, Kumar CM, Sattur AP. Strain improvement of Aspergillus niger for the enhanced production of asperenone. Indian J Microbiol. 2008 Jun;48(2):274-8. doi: 10.1007/s12088-008-0026-1. Epub 2008 Jun 13. PMID: 23100720; PMCID: PMC3450179. 2: Jefferson WE Jr. The isolation and characterization of asperenone, a new phenylpolyene from Aspergillus niger. Biochemistry. 1967 Nov;6(11):3479-84. doi: 10.1021/bi00863a019. PMID: 6073032. 3: Jefferson WE Jr. Steroids and other factors influenceing the accumulation of asperenone and fermentation acids by Aspergillus niger in replacement cultures. Biochemistry. 1967 Nov;6(11):3484-8. doi: 10.1021/bi00863a020. PMID: 6073033. 4: Mazumder K, Ruma YN, Akter R, Aktar A, Hossain MM, Shahina Z, Mazumdar S, Kerr PG. Identification of bioactive metabolites and evaluation of in vitro anti-inflammatory and in vivo antinociceptive and antiarthritic activities of endophyte fungi isolated from Elaeocarpus floribundus blume. J Ethnopharmacol. 2021 Jun 12;273:113975. doi: 10.1016/j.jep.2021.113975. Epub 2021 Feb 27. PMID: 33652111.