MedKoo Cat#: 414964 | Name: Piperazine phosphate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piperazine phosphate is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Piperazine was introduced to medicine as a solvent for uric acid.

Chemical Structure

Piperazine phosphate
Piperazine phosphate
CAS#18534-18-4 (phosphate)

Theoretical Analysis

MedKoo Cat#: 414964

Name: Piperazine phosphate

CAS#: 18534-18-4 (phosphate)

Chemical Formula: C4H15N2O5P

Exact Mass: 0.0000

Molecular Weight: 202.15

Elemental Analysis: C, 23.77; H, 7.48; N, 13.86; O, 39.57; P, 15.32

Price and Availability

Size Price Availability Quantity
1g USD 195.00 2 Weeks
5g USD 350.00 2 Weeks
25g USD 550.00 2 Weeks
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Synonym
Piperazine phosphate; Pincets; Pinsirup
IUPAC/Chemical Name
Piperazine phosphate (1:1), monohydrate
InChi Key
PMGABIJVFLPSLS-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H10N2.H3O4P.H2O/c1-2-6-4-3-5-1;1-5(2,3)4;/h5-6H,1-4H2;(H3,1,2,3,4);1H2
SMILES Code
O=P(O)(O)O.[H]O[H].N1CCNCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 202.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Screening of Transient Receptor Potential Canonical Channel Activators Identifies Novel Neurotrophic Piperazine Compounds. Mol Pharmacol. 2016 Mar;89(3):348-63. doi: 10.1124/mol.115.102863. Epub 2016 Jan 5. PubMed PMID: 26733543. 4: Walsh SP, Shahripour A, Tang H, de Jesus RK, Teumelsan N, Zhu Y, Frie J, Priest BT, Swensen AM, Alonso-Galicia M, Felix JP, Brochu RM, Bailey T, Thomas-Fowlkes B, Zhou X, Pai LY, Hampton C, Hernandez M, Owens K, Ehrhart J, Roy S, Kaczorowski GJ, Yang L, Garcia ML, Pasternak A. Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation. Bioorg Med Chem Lett. 2016 Mar 12. pii: S0960-894X(16)30255-4. doi: 10.1016/j.bmcl.2016.03.035. [Epub ahead of print] PubMed PMID: 27017115. 5: Al-Ghorbani M, Pavankumar GS, Naveen P, Thirusangu P, Prabhakar BT, Khanum SA. Synthesis and an angiolytic role of novel piperazine-benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development. Bioorg Chem. 2016 Apr;65:110-7. doi: 10.1016/j.bioorg.2016.02.006. Epub 2016 Feb 21. PubMed PMID: 26918263. 6: Park JA, Zhang D, Kim DS, Kim SK, Cho SH, Jeong D, Kim JS, Shim JH, Abd El-Aty AM, Shin HC. Development of a high-performance liquid chromatography with fluorescence detection method for quantification of piperazine in animal products by using precolumn derivatization. Food Chem. 2016 Apr 1;196:1331-7. doi: 10.1016/j.foodchem.2015.10.081. Epub 2015 Oct 19. PubMed PMID: 26593624. 7: Safbri SA, Halim SN, Jotani MM, Tiekink ER. Bis[N-(2-hy-droxy-eth-yl)-N-iso-propyl-dithio-carbamato-κ(2) S,S'](piperazine-κN)cadmium: crystal structure and Hirshfeld surface analysis. Acta Crystallogr E Crystallogr Commun. 2016 Jan 13;72(Pt 2):158-63. doi: 10.1107/S2056989016000165. eCollection 2016 Feb 1. PubMed PMID: 26958378; PubMed Central PMCID: PMC4770960. 8: Hong MN, Nam KY, Kim KK, Kim SY, Kim I. The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 Feb 12. [Epub ahead of print] PubMed PMID: 26873011. 9: Shimoda Y, Fujinaga M, Hatori A, Yui J, Zhang Y, Nengaki N, Kurihara Y, Yamasaki T, Xie L, Kumata K, Ishii H, Zhang MR. N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[(11)C]methylphenyl)thia zol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase. Bioorg Med Chem. 2016 Feb 15;24(4):627-34. doi: 10.1016/j.bmc.2015.12.026. Epub 2015 Dec 15. PubMed PMID: 26740152. 10: Patel RV, Syed R, Rathi AK, Lee YJ, Sung JS, Keum YS. Chrysin-piperazine conjugates as antioxidant and anticancer agents. Eur J Pharm Sci. 2016 Feb 23. pii: S0928-0987(16)30041-0. doi: 10.1016/j.ejps.2016.02.011. [Epub ahead of print] PubMed PMID: 26924226. 11: Huang P, Xu J, Qi G, Deng F, Xu R, Yan W. Temperature-dependence of the influence of the position-2-methyl group on the structure-directing effect of piperazine in the synthesis of open-framework aluminophosphates. Sci Rep. 2016 Feb 25;6:22019. doi: 10.1038/srep22019. PubMed PMID: 26912387; PubMed Central PMCID: PMC4766482. 12: Arbo MD, Melega S, Stöber R, Schug M, Rempel E, Rahnenführer J, Godoy P, Reif R, Cadenas C, de Lourdes Bastos M, Carmo H, Hengstler JG. Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis. Arch Toxicol. 2016 Jan 28. [Epub ahead of print] PubMed PMID: 26821219. 13: Lee MH. Bis(Naphthalimide-Piperazine)-Based Off-On Fluorescent Probe for Acids. J Fluoresc. 2016 Jan 13. [Epub ahead of print] PubMed PMID: 26758055. 14: Lamson NG, Cusimano G, Suri K, Zhang A, Whitehead KA. The pH of Piperazine Derivative Solutions Predicts Their Utility as Transepithelial Permeation Enhancers. Mol Pharm. 2016 Jan 13. [Epub ahead of print] PubMed PMID: 26730955. 15: Bobesh KA, Renuka J, Srilakshmi RR, Yellanki S, Kulkarni P, Yogeeswari P, Sriram D. Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors. Bioorg Med Chem. 2016 Jan 1;24(1):42-52. doi: 10.1016/j.bmc.2015.11.039. Epub 2015 Nov 28. PubMed PMID: 26678175. 16: Tekle-Röttering A, Jewell KS, Reisz E, Lutze HV, Ternes TA, Schmidt W, Schmidt TC. Ozonation of piperidine, piperazine and morpholine: Kinetics, stoichiometry, product formation and mechanistic considerations. Water Res. 2016 Jan 1;88:960-71. doi: 10.1016/j.watres.2015.11.027. Epub 2015 Nov 12. PubMed PMID: 26624229. 17: Swidorski JJ, Liu Z, Yin Z, Wang T, Carini DJ, Rahematpura S, Zheng M, Johnson K, Zhang S, Lin PF, Parker DD, Li W, Meanwell NA, Hamann LG, Regueiro-Ren A. Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore. Bioorg Med Chem Lett. 2016 Jan 1;26(1):160-7. doi: 10.1016/j.bmcl.2015.11.009. Epub 2015 Nov 5. PubMed PMID: 26584882. 18: Demirbaş Ü, Akyüz D, Mermer A, Akçay HT, Demirbaş N, Koca A, Kantekin H. The electrochemical and spectroelectrochemical properties of metal free and metallophthalocyanines containing triazole/piperazine units. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:478-87. doi: 10.1016/j.saa.2015.08.050. Epub 2015 Sep 3. PubMed PMID: 26397034. 19: Samie N, Muniandy S, Kanthimathi MS, Haerian BS. Mechanism of action of novel piperazine containing a toxicant against human liver cancer cells. PeerJ. 2016 Mar 17;4:e1588. doi: 10.7717/peerj.1588. eCollection 2016. PubMed PMID: 27019772; PubMed Central PMCID: PMC4806608. 20: Kumar JS, Devi TS, Ramkumaar GR, Bright A. Ab initio and density functional theory calculations of molecular structure and vibrational spectra of 4-(2-Hydroxyethyl) piperazine-1-ethanesulfonic acid. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5;152:509-22. doi: 10.1016/j.saa.2015.07.084. Epub 2015 Jul 23. PubMed PMID: 26278882.