Piperazine hexahydrate | CAS# 142-63-2 | Biochemical

MedKoo Cat#: 575023 | Name: Piperazine hexahydrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Piperazine hexahydrate is an anti-nematodal agent effective against the intestinal nematodes Ascaris Lumbricoides (roundworm) and Enterobius Vermicularis (pinworm, threadworm). It produces a neuromuscular block leading to flaccid muscle paralysis in susceptible worms, which are then dislodged from the gut and expelled in feces.

Chemical Structure

Piperazine hexahydrate

CAS#142-63-2 (hydrate)

Theoretical Analysis

MedKoo Cat#: 575023

Name: Piperazine hexahydrate

CAS#: 142-63-2 (hydrate)

Chemical Formula: C4H22N2O6

Exact Mass: 194.1478

Molecular Weight: 194.23

Elemental Analysis: C, 24.74; H, 11.42; N, 14.42; O, 49.42

Price and Availability

Size	Price	Availability	Quantity
5g	USD 150.00	2 Weeks
25g	USD 250.00	2 Weeks

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Related CAS #

110-85-0 (free base) 142-88-1 (adipate) 144-29-6 (citrate) 7140-78-5 (citrate hydrate) 142-63-2 (hydrate) 18534-18-4 (phosphate) 7433-23-0 (sebacate)

Synonym

AI3-26675; Arpezine; Arthriticine, Parid, Piperazine hexahydrate, Vermisol

IUPAC/Chemical Name

Piperazine, hexahydrate

InChi Key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

InChi Code

InChI=1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2

SMILES Code

O.O.O.O.O.O.C1CNCCN1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Piperazine hexahydrate is an anti-nematodal agent effective against the intestinal nematodes Ascaris Lumbricoides (roundworm) and Enterobius Vermicularis (pinworm, threadworm).

In vitro activity:

This work presents a library of 34 piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. The library was developed through a privileged structures-based design and then biologically screened using a live virus phenotypic assay to determine the half-maximal inhibitor concentration (IC50) of each compound against ZIKV and DENV. Two lead compounds, 42 and 44, with promising broad-spectrum activity against ZIKV (IC50 6.6 µM and 1.9 µM respectively) and DENV (IC50 6.7 µM and 1.4 µM respectively) and a good security profile were identified. Reference: Bioorg Chem. 2023 Apr;133:106408. https://pubmed.ncbi.nlm.nih.gov/36801791/

In vivo activity:

LPD (ligustrazine piperazine derivative) treatment dose-dependently reduced Aβ40 and Aβ42 levels in PC12 cells stably transfected with APP695swe and PSEN1dE9. Intragastric administration of LPD for 3 months dose-dependently reversed cognitive deficits in APP/PS1 mice. LPD treatment substantially decreased hippocampal Aβ plaques in APP/PS1 mice and decreased the levels of Aβ40 and Aβ42 in vivo and in vitro. Moreover, LPD treatment induced mitophagy in vivo and in vitro and increased brain 18F-FDG uptake in APP/PS1 mice. Reference: Alzheimers Res Ther. 2022 Oct 11;14(1):150. https://pubmed.ncbi.nlm.nih.gov/36217155/

	Solvent	mg/mL	mM	comments
Solubility
	Water	150.0	772.29

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 194.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Del Rosario García-Lozano M, Dragoni F, Gallego P, Mazzotta S, López-Gómez A, Boccuto A, Martínez-Cortés C, Rodríguez-Martínez A, Pérez-Sánchez H, Manuel Vega-Pérez J, Antonio Del Campo J, Vicenti I, Vega-Holm M, Iglesias-Guerra F. Piperazine-derived small molecules as potential Flaviviridae NS3 protease inhibitors. In vitro antiviral activity evaluation against Zika and Dengue viruses. Bioorg Chem. 2023 Apr;133:106408. doi: 10.1016/j.bioorg.2023.106408. Epub 2023 Feb 4. PMID: 36801791. 2. Liang T, Xie Z, Dang B, Wang J, Zhang T, Luan X, Lu T, Cao C, Chen X. Discovery of indole-piperazine derivatives as selective histone deacetylase 6 inhibitors with neurite outgrowth-promoting activities and neuroprotective activities. Bioorg Med Chem Lett. 2023 Feb 1;81:129148. doi: 10.1016/j.bmcl.2023.129148. Epub 2023 Jan 21. PMID: 36690041. 3. Li Z, Meng X, Ma G, Liu W, Li W, Cai Q, Wang S, Huang G, Zhang Y. Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice. Alzheimers Res Ther. 2022 Oct 11;14(1):150. doi: 10.1186/s13195-022-01092-7. PMID: 36217155; PMCID: PMC9552451. 4. Ni H, Hatit MZC, Zhao K, Loughrey D, Lokugamage MP, Peck HE, Cid AD, Muralidharan A, Kim Y, Santangelo PJ, Dahlman JE. Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nat Commun. 2022 Aug 15;13(1):4766. doi: 10.1038/s41467-022-32281-5. PMID: 35970837; PMCID: PMC9376583.

In vitro protocol:

In vivo protocol:

1. Li Z, Meng X, Ma G, Liu W, Li W, Cai Q, Wang S, Huang G, Zhang Y. Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice. Alzheimers Res Ther. 2022 Oct 11;14(1):150. doi: 10.1186/s13195-022-01092-7. PMID: 36217155; PMCID: PMC9552451. 2. Ni H, Hatit MZC, Zhao K, Loughrey D, Lokugamage MP, Peck HE, Cid AD, Muralidharan A, Kim Y, Santangelo PJ, Dahlman JE. Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nat Commun. 2022 Aug 15;13(1):4766. doi: 10.1038/s41467-022-32281-5. PMID: 35970837; PMCID: PMC9376583.