Pilsicainide Free Base | CAS# 88069-67-4 (free base) | antiarrhythmic agent

MedKoo Cat#: 414954 | Name: Pilsicainide Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pilsicainide Free Base is an antiarrhythmic agent.

Chemical Structure

Pilsicainide Free Base

CAS#88069-67-4 (free base)

Theoretical Analysis

MedKoo Cat#: 414954

Name: Pilsicainide Free Base

CAS#: 88069-67-4 (free base)

Chemical Formula: C17H24N2O

Exact Mass: 272.1889

Molecular Weight: 272.39

Elemental Analysis: C, 74.96; H, 8.88; N, 10.28; O, 5.87

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Related CAS #

88069-67-4 (free base); 88069-49-2 (HCl)

Synonym

Pilsicainide Free Base; Pilsicainida; Pilsicainidum

IUPAC/Chemical Name

1H-Pyrrolizine-7a(5H)-acetamide, N-(2,6-dimethylphenyl)tetrahydro-

InChi Key

BCQTVJKBTWGHCX-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H24N2O/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20)

SMILES Code

O=C(NC1=C(C)C=CC=C1C)CC23CCCN2CCC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 272.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Plosker GL. Pilsicainide. Drugs. 2010 Mar 5;70(4):455-67. doi: 10.2165/11204960-000000000-00000. PMID: 20205487. 2: Fukasawa M, Ninomiya K, Kawakami Y, Fuke C, Miyazaki T. Pilsicainide Poisoning: An Autopsy Case and Review of Literature. Am J Forensic Med Pathol. 2018 Dec;39(4):357-359. doi: 10.1097/PAF.0000000000000422. PMID: 30028738. 3: Kumagai K, Nakashima H, Tojo H, Yasuda T, Noguchi H, Matsumoto N, Ogawa M, Saku K. Pilsicainide for atrial fibrillation. Drugs. 2006;66(16):2067-73. doi: 10.2165/00003495-200666160-00003. PMID: 17112301. 4: Asano M, Hayakawa T, Kato Y, Kawada K, Goto S, Branch J, Shimizu H. Pilsicainide Intoxication with Neuropsychiatric Symptoms Treated with Continuous Hemodiafiltration. Intern Med. 2020 Sep 1;59(17):2191-2195. doi: 10.2169/internalmedicine.4676-20. Epub 2020 May 26. PMID: 32461529; PMCID: PMC7516329. 5: Hasebe H, Yokoya T, Murakoshi N, Kurebayashi N. Pilsicainide Administration Unmasks a Phenotype of Brugada Syndrome in a Patient with Overlap Syndrome due to the E1784K SCN5A Mutation. Intern Med. 2020 Jan 1;59(1):83-87. doi: 10.2169/internalmedicine.3430-19. Epub 2019 Sep 3. PMID: 31484910; PMCID: PMC6995720. 6: Onohara T, Hisatome I, Kurata Y, Li P, Notsu T, Morikawa K, Otani N, Yoshida A, Iitsuka K, Kato M, Miake J, Ninomiya H, Higaki K, Shirayoshi Y, Nishihara T, Itoh T, Nakamura Y, Nishimura M. Molecular mechanisms underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells. J Arrhythm. 2017 Jun;33(3):226-233. doi: 10.1016/j.joa.2016.09.003. Epub 2016 Oct 19. PMID: 28607619; PMCID: PMC5459418. 7: Numata T, Abe H, Nagatomo T, Kohshi K, Nakashima Y. Ventricular pacing failure after a single oral dose of pilsicainide in a patient with a permanent pacemaker and paroxysmal atrial fibrillation. Pacing Clin Electrophysiol. 2000 Sep;23(9):1436-8. doi: 10.1111/j.1540-8159.2000.tb00977.x. PMID: 11025904. 8: Saita T, Fujito H, Mori M. ELISA for the quantification of pilsicainide. Biol Pharm Bull. 2001 Oct;24(10):1113-6. doi: 10.1248/bpb.24.1113. PMID: 11642313. 9: Koike H, Fujino T, Koike M, Yao S, Shinohara M, Kitahara K, Kinoshita T, Yuzawa H, Suzuki T, Sato H, Fukunaga S, Kobayashi K, Ikeda T. Assessment of drug-induced proarrhythmias due to pilsicainide in patients with atrial tachyarrhythmias. J Arrhythm. 2016 Dec;32(6):468-473. doi: 10.1016/j.joa.2016.03.004. Epub 2016 May 26. PMID: 27920831; PMCID: PMC5129116. 10: Okishige K, Nishizaki M, Azegami K, Igawa M, Yamawaki N, Aonuma K; Kanagawa Arrhythmia Task Force investigators. Pilsicainide for conversion and maintenance of sinus rhythm in chronic atrial fibrillation: a placebo-controlled, multicenter study. Am Heart J. 2000 Sep;140(3):e13. doi: 10.1067/mhj.2000.107174. PMID: 10966544.