Pimethixene | CAS# 314-03-4 | antihistamine and anticholinergic

MedKoo Cat#: 412149 | Name: Pimethixene

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pimethixene or Calmixen is antihistamine and anticholinergic of the thioxanthene chemical class that is often used to treat hyperactivity, anxiety, sleep disorders, and allergy. It is also used for anesthesia and as a bronchodilator (to dilate the bronchi and bronchioles for more airflow).

Chemical Structure

Pimethixene

CAS#314-03-4

Theoretical Analysis

MedKoo Cat#: 412149

Name: Pimethixene

CAS#: 314-03-4

Chemical Formula: C19H19NS

Exact Mass: 293.1238

Molecular Weight: 293.42

Elemental Analysis: C, 77.77; H, 6.53; N, 4.77; S, 10.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Pimethixene; BP 400; BP-400; BP400; Calmixen

IUPAC/Chemical Name

1-Methyl-4-(thioxanthen-9-ylidene)piperidine

InChi Key

NZLVRVYNQYGMAB-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H19NS/c1-20-12-10-14(11-13-20)19-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)19/h2-9H,10-13H2,1H3

SMILES Code

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 293.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ding L, Zhao D, Zhou T, Jiang WK, Xiao CH. [Specific PCR Molecular Identification of Euconunmia Cortex]. Zhong Yao Cai. 2015 Apr;38(4):730-4. Chinese. PMID: 26672337. 2: Schmitz B, Ullmer C, Segelcke D, Gwarek M, Zhu XR, Lübbert H. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80. doi: 10.1016/j.ejphar.2015.01.043. Epub 2015 Feb 7. PMID: 25666387. 3: Soulère L, Sabbah M, Fontaine F, Queneau Y, Doutheau A. LuxR-dependent quorum sensing: computer aided discovery of new inhibitors structurally unrelated to N-acylhomoserine lactones. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4355-8. doi: 10.1016/j.bmcl.2010.06.081. Epub 2010 Jun 17. PMID: 20615699. 4: Chefneux A. Nouvelle thérapeutique de l'hyperkinésie chez l'enfant: le piméthixène [New treatment of hyperkinesis in the child: pimethixene]. Rev Med Liege. 1978 Jul 15;33(14):500-3. French. PMID: 674966. 5: Engelhardt G. Zur Pharmakologie des 9,10-Dihydro-10-(1-methyl-4-piperidyliden)-9-anthrol (WA 335), eines Histamin- und Serotoninantagonisten [On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist (author's transl)]. Arzneimittelforschung. 1975 Nov;25(11):1723-37. German. PMID: 1049. 6: Du Pan RM, Vuille G. A propos de la différence de sensibilité aux sédatifs entre le nourrisson et l'enfant d'âge scolaire. Etude d'un nouveau sédatif, le BP 400 [Difference in sensitivity to sedative drugs between infant and child of school age. Study of a new sedative, BP 400 (author's transl)]. Schweiz Rundsch Med Prax. 1975 Aug 19;64(33):1050-7. French. PMID: 1161751. 7: Alder A. Klinische Erfahrungen mit der Anwendung von Pimethixen in der Prämedikation bei Kindern [Clinical experience with the application of pimethixene in the premedication of children]. Anaesthesist. 1967 Sep;16(9):279-80. German. PMID: 4384909. 8: PATRIGNANI S, LADI MP, CAFFARINI E. PRIMI RILIEVI SULL'IMPIEGO DEL 9-(N-METIL-PIPERIDILIDEN-4')-TIOXANTENE (BP400) NELL TRATTAMENTO DELL'INSUFFICIENZA RESPIRATORIA OSTRUTTIVA [PRELIMINARY FINDINGS ON THE USE OF 9-(METHYL-4'-PIPERIDYLIDENE)-THIOXANTHENE (BP 400) IN THE TREATMENT OF OBSTRUCTIVE RESPIRATORY INSUFFICIENCY]. Riv Crit Clin Med. 1963 Oct;63:351-60. Italian. PMID: 14279395. 9: GIRARD JP. [Clinical trials of a new antiallergic substance, 9-(N-methyl-4-piperidylidene)-thioxasthene (BP 400)]. Schweiz Med Wochenschr. 1963 Mar 16;93:446-9. French. PMID: 13948138. 10: GIRARD JP. PROPRI'ET'ES ANTIANAPHYLACTIQUES DU 9-(N-M'ETHYLPIPERIDYLIDEN-4') THIOXANTHEN (BP 400) ET DU LYSOZYME, COMPAR'EES 'A CELLES DE LA PREDNISONE [ANTIANAPHYLACTIC PROPERTIES OF 9-(N-METHYL-4'-PIPERIDYLIDENE) THIOXANTHENE (BP 400) AND LYSOZYME, COMPARED TO THOSE OF PREDNISONE]. Med Exp Int J Exp Med. 1963;9:400-8. French. PMID: 14084232. 11: MUITTARI A. BP 400 IN BRONCHIAL ASTHMA. Acta Allergol. 1963;18:263-70. doi: 10.1111/j.1398-9995.1963.tb03180.x. PMID: 14059854.