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MedKoo Cat#: 465524 | Name: AC2P36

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AC2P36 is a novel inhibitor of Mycobacterium tuberculosis (Mtb), selectively killing Mtb at acidic pH and potentiating the bactericidal activity of isoniazid, clofazimine, and diamide.

Chemical Structure

AC2P36
AC2P36
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465524

Name: AC2P36

CAS#: unknown

Chemical Formula: C13H11Cl2N3O4S

Exact Mass: 374.9847

Molecular Weight: 376.21

Elemental Analysis: C, 41.50; H, 2.95; Cl, 18.85; N, 11.17; O, 17.01; S, 8.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AC2P36; AC 2P36; AC-2P36;
IUPAC/Chemical Name
5-chloro-N-(3-chloro-4-methoxyphenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide
InChi Key
AUVGGJLRPSKQAA-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11Cl2N3O4S/c1-22-10-4-3-7(5-8(10)14)17-12(19)11-9(15)6-16-13(18-11)23(2,20)21/h3-6H,1-2H3,(H,17,19)
SMILES Code
O=C(C1=NC(S(=O)(C)=O)=NC=C1Cl)NC2=CC=C(OC)C(Cl)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dechow SJ, Coulson GB, Wilson MW, Larsen SD, Abramovitch RB. AC2P20 selectively kills Mycobacterium tuberculosis at acidic pH by depleting free thiols. RSC Adv. 2021 Jun 4;11(33):20089-20100. doi: 10.1039/d1ra03181c. PMID: 34168865; PMCID: PMC8176622. 2: Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB. Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol. 2017 Aug 17;24(8):993-1004.e4. doi: 10.1016/j.chembiol.2017.06.018. Epub 2017 Aug 3. PMID: 28781126; PMCID: PMC5562523.