Synonym
GSK716; GSK 716; GSK-716;
IUPAC/Chemical Name
N-((1S,2R)-1-(3-fluoro-2-methylphenyl)-1-hydroxybutan-2-yl)-2-oxoindoline-4-carboxamide
InChi Key
GAAWCHLRDDENQF-APWZRJJASA-N
InChi Code
InChI=1S/C20H21FN2O3/c1-3-16(19(25)12-6-4-8-15(21)11(12)2)23-20(26)13-7-5-9-17-14(13)10-18(24)22-17/h4-9,16,19,25H,3,10H2,1-2H3,(H,22,24)(H,23,26)/t16-,19+/m1/s1
SMILES Code
O=C(N[C@@H]([C@@H](O)C1=CC=CC(F)=C1C)CC)C2=CC=CC3=C2CC(N3)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
356.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lomas DA, Irving JA, Arico-Muendel C, Belyanskaya S, Brewster A, Brown M, Chung CW, Dave H, Denis A, Dodic N, Dossang A, Eddershaw P, Klimaszewska D, Haq I, Holmes DS, Hutchinson JP, Jagger AM, Jakhria T, Jigorel E, Liddle J, Lind K, Marciniak SJ, Messer J, Neu M, Olszewski A, Ordonez A, Ronzoni R, Rowedder J, Rüdiger M, Skinner S, Smith KJ, Terry R, Trottet L, Uings I, Wilson S, Zhu Z, Pearce AC. Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin. EMBO Mol Med. 2021 Mar 5;13(3):e13167. doi: 10.15252/emmm.202013167. Epub 2021 Jan 29. PMID: 33512066; PMCID: PMC7933930.
2: Jagger AM, Waudby CA, Irving JA, Christodoulou J, Lomas DA. High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin. Nat Commun. 2020 Dec 11;11(1):6371. doi: 10.1038/s41467-020-20147-7. PMID: 33311470; PMCID: PMC7732992.
