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MedKoo Cat#: 465475 | Name: EX172

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EX172 is a dual Mer/Axl kinase inhibitor.

Chemical Structure

EX172
EX172
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465475

Name: EX172

CAS#: unknown

Chemical Formula: C34H41N7O2

Exact Mass: 579.3322

Molecular Weight: 579.75

Elemental Analysis: C, 70.44; H, 7.13; N, 16.91; O, 5.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
EX172; EX 172; EX-172;
IUPAC/Chemical Name
2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-((4'-((4-methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)methoxy)cyclopentyl)nicotinamide
InChi Key
GTVWQFJFCAUNFY-ACHIHNKUSA-N
InChi Code
InChI=1S/C34H41N7O2/c1-39-14-16-41(17-15-39)21-24-6-10-26(11-7-24)27-12-8-25(9-13-27)23-43-32-5-3-4-31(32)38-34(42)30-18-28(19-36-33(30)35)29-20-37-40(2)22-29/h6-13,18-20,22,31-32H,3-5,14-17,21,23H2,1-2H3,(H2,35,36)(H,38,42)/t31-,32-/m0/s1
SMILES Code
NC1=C(C(N[C@@H]2[C@@H](OCC3=CC=C(C4=CC=C(CN5CCN(C)CC5)C=C4)C=C3)CCC2)=O)C=C(C6=CN(C)N=C6)C=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 579.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Pflug A, Schimpl M, Nissink JWM, Overman RC, Rawlins PB, Truman C, Underwood E, Warwicker J, Winter-Holt J, McCoull W. A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding. Biochem J. 2020 Nov 27;477(22):4443-4452. doi: 10.1042/BCJ20200735. PMID: 33119085; PMCID: PMC7702301.