MedKoo Cat#: 561453 | Name: YUN27078
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

YUN27078, also known as EGFR inhibitor, is an EGFR inhibitor. YUN27078 directly depolymerizes microtubules and is used as a chemical probe to investigate both the EGFR pathway and microtubule dynamics. YUN27078 has CAS#879127-07-8. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

YUN27078
YUN27078
CAS#879127-07-8

Theoretical Analysis

MedKoo Cat#: 561453

Name: YUN27078

CAS#: 879127-07-8

Chemical Formula: C21H18F3N5O

Exact Mass: 413.1463

Molecular Weight: 413.40

Elemental Analysis: C, 61.01; H, 4.39; F, 13.79; N, 16.94; O, 3.87

Price and Availability

Size Price Availability Quantity
100mg USD 850.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,250.00 2 Weeks
1g USD 3,250.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
No Data
Synonym
EGFR inhibitor; EGFR-inhibitor; EGFRinhibitor; YUN27078; YUN-27078; YUN 27078;
IUPAC/Chemical Name
N-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
InChi Key
YOHYSYJDKVYCJI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(9-14)27-18-11-19(26-12-25-18)28-16-5-2-6-17(10-16)29-20(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,29,30)(H2,25,26,27,28)
SMILES Code
O=C(C1CC1)NC2=CC=CC(NC3=NC=NC(NC4=CC=CC(C(F)(F)F)=C4)=C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang, Q.,Liu, Y.,Gao, F., et al. Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. Journal of the American Chemical Society 128(7), 2182-2183 (2006). 2: Ciardiello, F., and Tortora, G. EGFR antagonists in cancer treatment. New England Journal of Medicine 358(11), 1160-1174 (2008). 3: Okamoto, K.,Okamoto, I.,Okamoto, W., et al. Role of survivin in EGFR inhibitor-induced apoptosis in non-small cell lung cancers positive for EGFR mutations. Cancer Research 70(24), 10402-10410 (2010).