MedKoo Cat#: 328018 | Name: Falipamil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Falipamil, also known as AQ-A-39, is a calcium channel antagonist potentially for the treatment of ischaemic heart disorder and sinus. Falipamil (AQ-A 39) is also a verapamil derivative which exerts antitachycardic effects by a direct action on the sinus node. Falipamil decreases HR at exercise in normal subjects and may exert antianginal effects in patients with myocardial ischemia. Falipamil exhibits effects on the electrical activity of the heart, reflecting the predominant direct vagolytic effect of this drug.

Chemical Structure

Falipamil
Falipamil
CAS#77862-92-1

Theoretical Analysis

MedKoo Cat#: 328018

Name: Falipamil

CAS#: 77862-92-1

Chemical Formula: C24H32N2O5

Exact Mass: 428.2311

Molecular Weight: 428.53

Elemental Analysis: C, 67.27; H, 7.53; N, 6.54; O, 18.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Falipamil; AQ-A-39; AQ-A 39; AQ-A39.
IUPAC/Chemical Name
2-(3-((3,4-dimethoxyphenethyl)(methyl)amino)propyl)-5,6-dimethoxyisoindolin-1-one
InChi Key
UUMGNNQOCVDZDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H32N2O5/c1-25(12-9-17-7-8-20(28-2)21(13-17)29-3)10-6-11-26-16-18-14-22(30-4)23(31-5)15-19(18)24(26)27/h7-8,13-15H,6,9-12,16H2,1-5H3
SMILES Code
O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CC3=C1C=C(OC)C(OC)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Boucher M, Chassaing C, Chapuy E. Cardiac electrophysiological effects of falipamil in the conscious dog: comparison with alinidine. Eur J Pharmacol. 1996 Jun 13;306(1-3):93-8. PubMed PMID: 8813620. 2: Boucher M, Chassaing C, Chapuy E, Duchêne-Marullaz P. Chronotropic cardiac effects of falipamil in conscious dogs: interactions with the autonomic nervous system and various ionic conductances. J Cardiovasc Pharmacol. 1994 Apr;23(4):569-75. PubMed PMID: 7516006. 3: Ilias W, Lackner F, Zimpfer M. [The intraoperative use of falipamil (AQ-A39), a new calcium antagonist with specific bradytropic properties]. Anaesthesist. 1990 Oct;39(10):487-92. German. PubMed PMID: 2278367. 4: Roth W, Koss FW, Hallinan D, Lambe R, Darragh A. Pharmacokinetics of falipamil after intravenous administration to humans. J Pharm Sci. 1990 May;79(5):415-9. PubMed PMID: 2352161. 5: Naudascher M, Jaillon P, Lecocq B, Lecocq V, Ferry A, Hilaire J, Maria JF. Effects of falipamil (AQ-A 39) on heart rate and blood pressure in resting and exercising healthy volunteers. J Cardiovasc Pharmacol. 1989 Jul;14(1):1-5. PubMed PMID: 2475699. 6: Takeda M, Furukawa Y, Ogiwara Y, Saegusa K, Haniuda M, Akahane K, Chiba S. Effects on atrio-ventricular conduction of alinidine and falipamil injected into the AV node artery of the anesthetized dog. Arch Int Pharmacodyn Ther. 1989 Jan-Feb;297:39-48. PubMed PMID: 2730241. 7: Ogiwara Y, Furukawa Y, Akahane K, Haniuda M, Chiba S. Bradycardic effects of AQ-A 39 (falipamil) in situ and in isolated, blood-perfused dog hearts. Comparison with alinidine and verapamil. Jpn Heart J. 1988 Nov;29(6):849-61. PubMed PMID: 3241338. 8: Huemer G, Hlozanek C, Lackner F, Niederle B, Schernthaner G, Schwarz S, Ilias W, Zimpfer M. [Falipamil for decreasing intraoperative heart rate in pheochromocytoma]. Acta Med Austriaca. 1988;15(4):103-5. German. PubMed PMID: 3213376. 9: Gülker H. A summary of the acute effects of falipamil in man. Eur Heart J. 1987 Dec;8 Suppl L:141-6. Review. PubMed PMID: 3330525. 10: Lévy S, Mètge M, Hilaire J, Cointe R, Bru P, Eychenne JL, Gérard R. Electrophysiologic properties of falipamil (AQA-39)--a new bradycardiac agent. Eur Heart J. 1987 Nov;8(11):1236-40. PubMed PMID: 3691560. 11: Tryba M, Zenz M. [Therapy of perioperative sinus tachycardia with the new calcium antagonist falipamil]. Arzneimittelforschung. 1987 Nov;37(11):1298-300. German. PubMed PMID: 3440040. 12: Gross GJ, Daemmgen JW. Effect of the new specific bradycardia agent AQ-A39 (falipamil) on coronary collateral blood flow in dogs. J Cardiovasc Pharmacol. 1987 Jul;10(1):123-7. PubMed PMID: 2441148. 13: Gross GJ, Daemmgen JW. Beneficial effects of two specific bradycardic agents AQ-A39 (falipamil) and AQ-AH 208 on reversible myocardial reperfusion damage in anesthetized dogs. J Pharmacol Exp Ther. 1986 Aug;238(2):422-8. PubMed PMID: 3735124.