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MedKoo Cat#: 574940 | Name: YM-60828 dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease.

Chemical Structure

YM-60828 dihydrochloride
YM-60828 dihydrochloride
CAS#179755-65-8

Theoretical Analysis

MedKoo Cat#: 574940

Name: YM-60828 dihydrochloride

CAS#: 179755-65-8

Chemical Formula: C27H33Cl2N5O5S

Exact Mass: 609.1579

Molecular Weight: 610.55

Elemental Analysis: C, 53.12; H, 5.45; Cl, 11.61; N, 11.47; O, 13.10; S, 5.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
YM 60828; YM60828; YM-60828 dihydrochloride; YM-60828 HCl; YM-60828 2HCl
IUPAC/Chemical Name
2-[[[[7-(Aminoiminomethyl)-2-naphthalenyl]methyl][4-[[1-(1-iminoethyl)-4-piperidinyl]oxy]phenyl]amino]sulfonyl]acetic Acid Dihydrochloride
InChi Key
GKELESGQQAPAAO-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H31N5O5S.2ClH/c1-18(28)31-12-10-25(11-13-31)37-24-8-6-23(7-9-24)32(38(35,36)17-26(33)34)16-19-2-3-20-4-5-21(27(29)30)15-22(20)14-19;;/h2-9,14-15,25,28H,10-13,16-17H2,1H3,(H3,29,30)(H,33,34);2*1H
SMILES Code
O=C(O)CS(=O)(N(CC1=CC=C2C=CC(C(N)=N)=CC2=C1)C3=CC=C(OC4CCN(C(C)=N)CC4)C=C3)=O.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 610.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Sato K, Kawasaki T, Taniuchi Y, Hirayama F, Koshio H, Matsumoto Y. YM-60828, a novel factor Xa inhibitor: separation of its antithrombotic effects from its prolongation of bleeding time. Eur J Pharmacol. 1997 Nov 27;339(2-3):141-6. doi: 10.1016/s0014-2999(97)01389-7. PMID: 9473127. 2. Sato K, Kawasaki T, Hisamichi N, Taniuchi Y, Hirayama F, Koshio H, Matsumoto Y. Antithrombotic effects of YM-60828, a newly synthesized factor Xa inhibitor, in rat thrombosis models and its effects on bleeding time. Br J Pharmacol. 1998 Jan;123(1):92-6. doi: 10.1038/sj.bjp.0701566. PMID: 9484858; PMCID: PMC1565130. 3. Hirayama F, Koshio H, Katayama N, Kurihara H, Taniuchi Y, Sato K, Hisamichi N, Sakai-Moritani Y, Kawasaki T, Matsumoto Y, Yanagisawa I. The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor. Bioorg Med Chem. 2002 May;10(5):1509-23. doi: 10.1016/s0968-0896(01)00418-7. PMID: 11886813.