Synonym
FFENM HCl; FFENM hydrochloride; Fluoroethylnormemantine HCl; Fluoroethylnormemantine hydrochloride;
IUPAC/Chemical Name
(1s,3r,5R,7S)-3-(2-fluoroethyl)adamantan-1-amine hydrochloride
InChi Key
KPURUIUXBWTRPB-VXMZOEJHSA-N
InChi Code
InChI=1S/C12H20FN.ClH/c13-2-1-11-4-9-3-10(5-11)7-12(14,6-9)8-11;/h9-10H,1-8,14H2;1H/t9-,10+,11-,12-;
SMILES Code
N[C@@]12C[C@@H]3C[C@H](C2)C[C@@](C1)(CCF)C3.Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
233.76
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chen BK, Luna VM, Shannon ME, Hunsberger HC, Mastrodonato A, Stackmann M, McGowan JC, Rubinstenn G, Denny CA. Fluoroethylnormemantine, a Novel NMDA Receptor Antagonist, for the Prevention and Treatment of Stress-Induced Maladaptive Behavior. Biol Psychiatry. 2021 May 9:S0006-3223(21)01298-1. doi: 10.1016/j.biopsych.2021.04.024. Epub ahead of print. PMID: 34274107.
2: Chen BK, Le Pen G, Eckmier A, Rubinstenn G, Jay TM, Denny CA. Fluoroethylnormemantine, A Novel Derivative of Memantine, Facilitates Extinction Learning Without Sensorimotor Deficits. Int J Neuropsychopharmacol. 2021 Jul 14;24(6):519-531. doi: 10.1093/ijnp/pyab007. PMID: 33631001; PMCID: PMC8278800.
3: Couly S, Denus M, Bouchet M, Rubinstenn G, Maurice T. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease. Int J Neuropsychopharmacol. 2021 Feb 15;24(2):142-157. doi: 10.1093/ijnp/pyaa075. PMID: 32977336; PMCID: PMC7883897.
4: Salabert AS, Mora-Ramirez E, Beaurain M, Alonso M, Fontan C, Tahar HB, Boizeau ML, Tafani M, Bardiès M, Payoux P. Evaluation of [18F]FNM biodistribution and dosimetry based on whole-body PET imaging of rats. Nucl Med Biol. 2018 Apr;59:1-8. doi: 10.1016/j.nucmedbio.2017.12.003. Epub 2017 Dec 21. PMID: 29413751.
5: Salabert AS, Fonta C, Fontan C, Adel D, Alonso M, Pestourie C, Belhadj-Tahar H, Tafani M, Payoux P. Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors. Nucl Med Biol. 2015 Aug;42(8):643-53. doi: 10.1016/j.nucmedbio.2015.04.001. Epub 2015 Apr 7. PMID: 25963911.
