6-MITC | CAS#4430-35-7 | cell viability inhibitor

MedKoo Cat#: 563098 | Name: 6-MITC

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

6-MITC is an inhibitor of viability of both PANC-1 and BxPC-3 cells. It also acts as an inhibitor of the expression of CSC signaling molecule SOX2.

Chemical Structure

6-MITC

CAS#4430-35-7

Theoretical Analysis

MedKoo Cat#: 563098

Name: 6-MITC

CAS#: 4430-35-7

Chemical Formula: C8H15NOS2

Exact Mass: 205.0595

Molecular Weight: 205.33

Elemental Analysis: C, 46.80; H, 7.36; N, 6.82; O, 7.79; S, 31.23

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 weeks
10mg	USD 600.00	2 weeks
25mg	USD 1,150.00	2 weeks

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Related CAS #

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Synonym

6-MITC; 6 MITC; 6MITC; Hesperin; 6-MSITC

IUPAC/Chemical Name

6-(Methylsulfinyl)hexyl isothiocyanate

InChi Key

XQZVZULJKVALRI-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H15NOS2/c1-12(10)7-5-3-2-4-6-9-8-11/h2-7H2,1H3

SMILES Code

O=S(CCCCCCN=C=S)C

Appearance

A solution in ethanol

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 205.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PubMed PMID: 29340085; PubMed Central PMCID: PMC5762353. 4: Trio PZ, Fujisaki S, Tanigawa S, Hisanaga A, Sakao K, Hou DX. DNA Microarray Highlights Nrf2-Mediated Neuron Protection Targeted by Wasabi-Derived Isothiocyanates in IMR-32 Cells. Gene Regul Syst Bio. 2016 Aug 11;10:73-83. doi: 10.4137/GRSB.S39440. eCollection 2016. PubMed PMID: 27547033; PubMed Central PMCID: PMC4982521. 5: Morroni F, Sita G, Tarozzi A, Cantelli-Forti G, Hrelia P. Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease. Brain Res. 2014 Nov 17;1589:93-104. doi: 10.1016/j.brainres.2014.09.033. Epub 2014 Sep 23. PubMed PMID: 25257035. 6: Fuke Y, Hishinuma M, Namikawa M, Oishi Y, Matsuzaki T. Wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate induces apoptosis in human breast cancer by possible involvement of the NF-κB pathways. Nutr Cancer. 2014;66(5):879-87. doi: 10.1080/01635581.2014.916322. Epub 2014 Jun 4. PubMed PMID: 24895898. 7: Chen YJ, Huang YC, Tsai TH, Liao HF. Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. Evid Based Complement Alternat Med. 2014;2014:494739. doi: 10.1155/2014/494739. Epub 2014 Jan 20. PubMed PMID: 24575144; PubMed Central PMCID: PMC3918374. 8: Yamaguchi H, Kamiie K, Kidachi Y, Noshita T, Umetsu H, Fuke Y, Ryoyama K. Intracellular accumulation of structurally varied isothiocyanates correlates with inhibition of nitric oxide production in proinflammatory stimuli-activated tumorigenic macrophage-like cells. Bioorg Med Chem. 2014 Jan 1;22(1):440-6. doi: 10.1016/j.bmc.2013.11.008. Epub 2013 Nov 12. PubMed PMID: 24268367. 9: Reisenauer HP, Romański J, Mlostoń G, Schreiner PR. Matrix isolation and spectroscopic properties of the methylsulfinyl radical CH3(O)S˙. Chem Commun (Camb). 2013 Oct 21;49(82):9467-9. doi: 10.1039/c3cc45379k. PubMed PMID: 24013766. 10: Yamaguchi H, Kidachi Y, Kamiie K, Noshita T, Umetsu H, Fuke Y, Ryoyama K. Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies. Biochem Pharmacol. 2013 Aug 15;86(4):458-68. doi: 10.1016/j.bcp.2013.06.008. Epub 2013 Jun 19. PubMed PMID: 23791871. 11: Yamaguchi H, Kidachi Y, Kamiie K, Noshita T, Umetsu H. Homology modeling and structural analysis of human P-glycoprotein. Bioinformation. 2012;8(22):1066-74. doi: 10.6026/97320630081066. Epub 2012 Nov 13. PubMed PMID: 23251040; PubMed Central PMCID: PMC3523220. 12: Uto T, Hou DX, Morinaga O, Shoyama Y. Molecular Mechanisms Underlying Anti-Inflammatory Actions of 6-(Methylsulfinyl)hexyl Isothiocyanate Derived from Wasabi (Wasabia japonica). Adv Pharmacol Sci. 2012;2012:614046. doi: 10.1155/2012/614046. Epub 2012 Aug 15. PubMed PMID: 22927840; PubMed Central PMCID: PMC3426159. 13: Uchida K, Miura Y, Nagai M, Tominaga M. Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel. Chem Senses. 2012 Nov;37(9):809-18. doi: 10.1093/chemse/bjs065. Epub 2012 Aug 6. PubMed PMID: 22869685. 14: Hou DX, Korenori Y, Tanigawa S, Yamada-Kato T, Nagai M, He X, He J. Dynamics of Nrf2 and Keap1 in ARE-mediated NQO1 expression by wasabi 6-(methylsulfinyl)hexyl isothiocyanate. J Agric Food Chem. 2011 Nov 23;59(22):11975-82. doi: 10.1021/jf2032439. Epub 2011 Nov 1. PubMed PMID: 22010800. 15: Mizuno K, Kume T, Muto C, Takada-Takatori Y, Izumi Y, Sugimoto H, Akaike A. Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. J Pharmacol Sci. 2011;115(3):320-8. Epub 2011 Feb 24. PubMed PMID: 21358121. 16: Yoshida J, Nomura S, Nishizawa N, Ito Y, Kimura K. Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum). Biosci Biotechnol Biochem. 2011;75(1):136-9. Epub 2011 Jan 7. PubMed PMID: 21228474. 17: Chen J, Uto T, Tanigawa S, Yamada-Kato T, Fujii M, Hou DX. Microarray-based determination of anti-inflammatory genes targeted by 6-(methylsulfinyl)hexyl isothiocyanate in macrophages. Exp Ther Med. 2010 Jan;1(1):33-40. Epub 2010 Jan 1. PubMed PMID: 23136589; PubMed Central PMCID: PMC3490381. 18: Nomura T, Uehara Y, Kawajiri H, Ryoyama K, Yamori T, Fuke Y. Alkyl isothiocyanates suppress epidermal growth factor receptor kinase activity but augment tyrosine kinase activity. Cancer Epidemiol. 2009 Oct;33(3-4):288-92. doi: 10.1016/j.canep.2009.08.009. Epub 2009 Sep 22. PubMed PMID: 19775950. 19: Noshita T, Kidachi Y, Funayama H, Kiyota H, Yamaguchi H, Ryoyama K. Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity. Eur J Med Chem. 2009 Dec;44(12):4931-6. doi: 10.1016/j.ejmech.2009.08.005. Epub 2009 Aug 18. PubMed PMID: 19716210. 20: Kidachi Y, Noshita T, Yamaguchi H, Umetsu H, Fuke Y, Ryoyama K. The augmenting activity of 6-(methylsulfinyl)hexyl isothiocyanate on cellular glutathione levels is less sensitive to thiol compounds than its cytotoxic activity. Biosci Biotechnol Biochem. 2009 Jun;73(6):1419-21. Epub 2009 Jun 7. PubMed PMID: 19502751.