PD 154075 | CAS# 158991-23-2 | Non-peptide tachykinin NK1 receptor antagonist

MedKoo Cat#: 44810 | Name: PD 154075

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 154075 is a a non-peptide tachykinin NK1 receptor antagonist.

Chemical Structure

PD 154075

CAS#158991-23-2

Theoretical Analysis

MedKoo Cat#: 44810

Name: PD 154075

CAS#: 158991-23-2

Chemical Formula: C30H29N3O4

Exact Mass: 495.2158

Molecular Weight: 495.58

Elemental Analysis: C, 72.71; H, 5.90; N, 8.48; O, 12.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

PD 154075; PD154075; PD-154075; CI-1021; CI1021; CI 1021

IUPAC/Chemical Name

Carbamic acid, N-((1R)-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-(((1S)-1-phenylethyl)amino)ethyl)-, 2-benzofuranylmethyl ester

InChi Key

IVIQHHCTWSXXCT-WENCNXQZSA-N

InChi Code

InChI=1S/C30H29N3O4/c1-20(21-10-4-3-5-11-21)32-28(34)30(2,17-23-18-31-26-14-8-7-13-25(23)26)33-29(35)36-19-24-16-22-12-6-9-15-27(22)37-24/h3-16,18,20,31H,17,19H2,1-2H3,(H,32,34)(H,33,35)/t20-,30+/m0/s1

SMILES Code

O=C(OCC1=CC2=CC=CC=C2O1)N[C@](C)(CC3=CNC4=C3C=CC=C4)C(N[C@H](C5=CC=CC=C5)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 495.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Singh L, Field MJ, Hughes J, Kuo BS, Suman-Chauhan N, Tuladhar BR, Wright DS, Naylor RJ. The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin- induced delayed emesis in the ferret. Eur J Pharmacol. 1997 Feb 26;321(2):209-16. doi: 10.1016/s0014-2999(96)00950-8. PMID: 9063690. 2: Gonzalez MI, Field MJ, Holloman EF, Hughes J, Oles RJ, Singh L. Evaluation of PD 154075, a tachykinin NK1 receptor antagonist, in a rat model of postoperative pain. Eur J Pharmacol. 1998 Mar 5;344(2-3):115-20. doi: 10.1016/s0014-2999(97)01581-1. PMID: 9600644. 3: Horwell D, Pritchard M, Raphy J, Ratcliffe G. 'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors. Immunopharmacology. 1996 Jun;33(1-3):68-72. doi: 10.1016/0162-3109(96)00058-6. PMID: 8856117. 4: Boyle S, Guard S, Higginbottom M, Horwell DC, Howson W, McKnight AT, Martin K, Pritchard MC, O'Toole J, Raphy J, et al. Rational design of high affinity tachykinin NK1 receptor antagonists. Bioorg Med Chem. 1994 May;2(5):357-70. doi: 10.1016/s0968-0896(00)82192-6. PMID: 7922147. 5: Zhu Z, Chen HG, Goel OP, Chan OH, Stilgenbauer LA, Stewart BH. Phosphate prodrugs of PD154075. Bioorg Med Chem Lett. 2000 May 15;10(10):1121-4. doi: 10.1016/s0960-894x(00)00183-9. PMID: 10843232.