EMAC10101d | CAS#2561476-24-0 | Carbonic Anhydrase Isoform inhibitor

MedKoo Cat#: 555915 | Name: EMAC10101d

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EMAC10101d is a potent and selective inhibitor of Carbonic Anhydrase Isoform toward hCA II with an inhibitory activity in the low nanomolar range.

Chemical Structure

EMAC10101d

CAS#2561476-24-0

Theoretical Analysis

MedKoo Cat#: 555915

Name: EMAC10101d

CAS#: 2561476-24-0

Chemical Formula: C17H15Cl2N3O2S2

Exact Mass: 426.9983

Molecular Weight: 428.35

Elemental Analysis: C, 47.67; H, 3.53; Cl, 16.55; N, 9.81; O, 7.47; S, 14.97

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
200mg	USD 1,650.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,450.00	2 Weeks
2g	USD 5,650.00	2 Weeks

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Related CAS #

No Data

Synonym

EMAC10101d; EMAC-10101d; EMAC 10101d

IUPAC/Chemical Name

(Z)-4-((4-(2,4-dichlorophenyl)-3-ethylthiazol-2(3H)-ylidene)amino)benzenesulfonamide

InChi Key

OEGLVUQKHJHUEU-FXBPSFAMSA-N

InChi Code

InChI=1S/C17H15Cl2N3O2S2/c1-2-22-16(14-8-3-11(18)9-15(14)19)10-25-17(22)21-12-4-6-13(7-5-12)26(20,23)24/h3-10H,2H2,1H3,(H2,20,23,24)/b21-17-

SMILES Code

O=S(C1=CC=C(/N=C2SC=C(C3=CC=C(Cl)C=C3Cl)N\2CC)C=C1)(N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 428.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Meleddu R, Distinto S, Cottiglia F, Angius R, Caboni P, Angeli A, Melis C, Deplano S, Alcaro S, Ortuso F, Supuran CT, Maccioni E. New Dihydrothiazole Benzensulfonamides: Looking for Selectivity toward Carbonic Anhydrase Isoforms I, II, IX, and XII. ACS Med Chem Lett. 2020 Feb 13;11(5):852-856. doi: 10.1021/acsmedchemlett.9b00644. PMID: 32435395; PMCID: PMC7236253.