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MedKoo Cat#: 414787 | Name: Tranylcypromine Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tranylcypromine Free Base is a propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders.

Chemical Structure

Tranylcypromine Free Base
Tranylcypromine Free Base
CAS#155-09-9 (free base)

Theoretical Analysis

MedKoo Cat#: 414787

Name: Tranylcypromine Free Base

CAS#: 155-09-9 (free base)

Chemical Formula: C9H11N

Exact Mass: 133.0891

Molecular Weight: 133.19

Elemental Analysis: C, 81.16; H, 8.32; N, 10.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
13492-01-8 (sulfate) 155-09-9 (free base) 54779-58-7 (Cis_HCl) 4548-34-9 (HCl)
Synonym
Tranylcypromine Free Base; CCRIS3344; CCRIS-3344; CCRIS 3344; HSDB3404; HSDB-3404; HSDB 3404
IUPAC/Chemical Name
Cyclopropanamine, 2-phenyl-, (1R,2S)-rel-
InChi Key
AELCINSCMGFISI-DTWKUNHWSA-N
InChi Code
InChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m0/s1
SMILES Code
N[C@H]1[C@H](C2=CC=CC=C2)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 133.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dai XJ, Liu Y, Xiong XP, Xue LP, Zheng YC, Liu HM. Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective. J Med Chem. 2020 Dec 10;63(23):14197-14215. doi: 10.1021/acs.jmedchem.0c00919. Epub 2020 Sep 30. Erratum in: J Med Chem. 2021 May 13;64(9):6412. PMID: 32931269. 2: LEES F, BURKE CW. Tranylcypromine. Lancet. 1963 Jan 5;1(7271):13-6. doi: 10.1016/s0140-6736(63)91144-9. PMID: 13929197. 3: Atkinson RM, Ditman KS. Tranylcypromine: a review. Clin Pharmacol Ther. 1965 Sep-Oct;6(5):631-55. doi: 10.1002/cpt196565631. PMID: 5320592. 4: Heijnen WT, De Fruyt J, Wierdsma AI, Sienaert P, Birkenhäger TK. Efficacy of Tranylcypromine in Bipolar Depression: A Systematic Review. J Clin Psychopharmacol. 2015 Dec;35(6):700-5. doi: 10.1097/JCP.0000000000000409. PMID: 26479223. 5: Ulrich S, Ricken R, Adli M. Tranylcypromine in mind (Part I): Review of pharmacology. Eur Neuropsychopharmacol. 2017 Aug;27(8):697-713. doi: 10.1016/j.euroneuro.2017.05.007. Epub 2017 Jun 24. PMID: 28655495. 6: Wang X, Su M, Li Y, Liu T, Wang Y, Chen Y, Tang L, He YP, Ding X, Yu F, Shen J, Li J, Zhou Y, Chen YL, Xiong B. Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor. Bioorg Med Chem Lett. 2019 Mar 15;29(6):844-847. doi: 10.1016/j.bmcl.2019.01.017. Epub 2019 Jan 18. PMID: 30713023. 7: Frieling H, Bleich S. Tranylcypromine: new perspectives on an "old" drug. Eur Arch Psychiatry Clin Neurosci. 2006 Aug;256(5):268-73. doi: 10.1007/s00406-006-0660-8. PMID: 16927039. 8: Park H, Han KM, Jeon H, Lee JS, Lee H, Jeon SG, Park JH, Kim YG, Lin Y, Lee YH, Jeong YH, Hoe HS. The MAO Inhibitor Tranylcypromine Alters LPS- and Aβ- Mediated Neuroinflammatory Responses in Wild-type Mice and a Mouse Model of AD. Cells. 2020 Aug 28;9(9):1982. doi: 10.3390/cells9091982. PMID: 32872335; PMCID: PMC7563969. 9: Fioravanti R, Romanelli A, Mautone N, Di Bello E, Rovere A, Corinti D, Zwergel C, Valente S, Rotili D, Botrugno OA, Dessanti P, Vultaggio S, Vianello P, Cappa A, Binda C, Mattevi A, Minucci S, Mercurio C, Varasi M, Mai A. Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation. ChemMedChem. 2020 Apr 3;15(7):643-658. doi: 10.1002/cmdc.201900730. Epub 2020 Feb 14. PMID: 32003940; PMCID: PMC7125024. 10: van der Heide D, Merckelbach H, van Harten P. Tranylcypromine en khat: een potentieel fatale combinatie [Tranylcypromine and khat: a potentially fatal combination]. Tijdschr Psychiatr. 2018;60(8):544-547. Dutch. PMID: 30132583.