MedKoo Cat#: 574916 | Name: Tranylcypromine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tranylcypromine hydrochloride is a non-selective, irreversible inhibitor of monoamine oxidase (MAO), primarily targeting MAO-A and MAO-B. By inhibiting MAO, it prevents the breakdown of neurotransmitters such as serotonin, norepinephrine, and dopamine, leading to increased synaptic levels and enhanced neurotransmission. Clinically, tranylcypromine hydrochloride is used as an antidepressant for treating major depressive disorder (MDD), particularly in cases resistant to other treatments.

Chemical Structure

Tranylcypromine hydrochloride
Tranylcypromine hydrochloride
CAS#4548-34-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 574916

Name: Tranylcypromine hydrochloride

CAS#: 4548-34-9 (HCl)

Chemical Formula: C9H12ClN

Exact Mass: 169.0658

Molecular Weight: 169.65

Elemental Analysis: C, 63.72; H, 7.13; Cl, 20.90; N, 8.26

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Related CAS #
Synonym
Tranylcypromine hydrochloride; Tranylcypromine HCl
IUPAC/Chemical Name
(1S,2R)-2-phenylcyclopropan-1-amine hydrochloride
InChi Key
ZPEFMSTTZXJOTM-RJUBDTSPSA-N
InChi Code
InChI=1S/C9H11N.ClH/c10-9-6-8(9)7-4-2-1-3-5-7;/h1-5,8-9H,6,10H2;1H/t8-,9+;/m1./s1
SMILES Code
N[C@H]1C[C@@H]1C2=CC=CC=C2.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 169.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Akinci M, Karadag CH, Huseyin S, Oltulu C, Canbaz S, Gunduz O, Topuz RD. Effects of in vitro Amitriptyline, Fluoxetine, Tranylcypromine and Venlafaxine on Saphenous Vein Grafts. Braz J Cardiovasc Surg. 2019 Jun 1;34(3):290-296. doi: 10.21470/1678-9741-2018-0338. PMID: 31310467; PMCID: PMC6629227. 2. Valente S, Rodriguez V, Mercurio C, Vianello P, Saponara B, Cirilli R, Ciossani G, Labella D, Marrocco B, Monaldi D, Ruoppolo G, Tilset M, Botrugno OA, Dessanti P, Minucci S, Mattevi A, Varasi M, Mai A. Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts. Eur J Med Chem. 2015 Apr 13;94:163-74. doi: 10.1016/j.ejmech.2015.02.060. Epub 2015 Mar 3. PMID: 25768700.