Related CAS #
61484-38-6 (free base); 63236-23-7 (HCl); 61484-39-7 (sulfate)
Synonym
Pareptide sulfate; AY24,856; AY 24,856; AY-24,856
IUPAC/Chemical Name
Glycinamide, L-prolyl-N-methyl-D-leucyl-, sulfate (2:1)
InChi Key
DPOZYRPNCJEMMY-DDRMSGASSA-N
InChi Code
InChI=1S/2C14H26N4O3.H2O4S/c2*1-9(2)7-11(13(20)17-8-12(15)19)18(3)14(21)10-5-4-6-16-10;1-5(2,3)4/h2*9-11,16H,4-8H2,1-3H3,(H2,15,19)(H,17,20);(H2,1,2,3,4)/t2*10-,11+;/m00./s1
SMILES Code
O=C(N)CNC([C@@H](CC(C)C)N(C([C@H]1NCCC1)=O)C)=O.O=C(N)CNC([C@@H](CC(C)C)N(C([C@H]2NCCC2)=O)C)=O.O=S(O)(O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
694.85
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mycroft FJ, Bhargava HN, Wei ET. Pharmacological activities of the MIF-1 analogues Pro-Leu-Gly, Tyr-Pro-Leu-Gly and pareptide. Peptides. 1987 Nov- Dec;8(6):1051-5. doi: 10.1016/0196-9781(87)90135-5. PMID: 2894644.
2: Krol GJ, Banovsky JM, Mannan CA, Pickering RE, Kho BT. Trace analysis of the MIF analogue pareptide in blood plasma by high-performance liquid chromatography and short-wavelength excitation fluorometry. J Chromatogr. 1979 Aug 21;163(4):383-9. doi: 10.1016/s0378-4347(00)81641-2. PMID: 544604.
3: Mycroft FJ, Wei ET. Pro-Leu-Gly-NH2 and pareptide inhibit development of tolerance to haloperidol catalepsy in the mouse. Peptides. 1984 Sep- Oct;5(5):883-7. doi: 10.1016/0196-9781(84)90111-6. PMID: 6150468.
4: Hui KS, Cheng KP, Wong KH, Salschutz M, Lajtha A. Degradation of melanotropin inhibiting factor by brain. J Neurochem. 1980 Aug;35(2):471-8. doi: 10.1111/j.1471-4159.1980.tb06289.x. PMID: 6108995.
5: Hui KS, Hui M, Cheng KP, Lajtha A, Boksay I, Fencik MU. Determination of the melanotropin-inhibiting factor analogue pareptide in urine by high-performance liquid chromatography. J Chromatogr. 1981 Mar 13;222(3):512-7. doi: 10.1016/s0378-4347(00)84157-2. PMID: 6112231.
6: Neidle A, Yessaian N, Lajtha A. Degradation of prolylleucylglycinamide (MIF) by mouse brain. Neurochem Res. 1980 Sep;5(9):1011-23. doi: 10.1007/BF00966139. PMID: 6111031.
7: Turnbull MJ, Wheeler H. Some observations on the pharmacological activity of MIF (Pro-Leu-Gly-NH2). J Pharm Pharmacol. 1980 Nov;32(11):803-4. doi: 10.1111/j.2042-7158.1980.tb13078.x. PMID: 6110739.
