BC1618 is a Fbxo48 inhibitor which prevents pAMPKα degradation and ameliorates insulin resistance. BC1618 increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice.
MedKoo Cat#: 408161
Name: BC1618
CAS#: 2222094-18-8
Chemical Formula: C24H24F3NO2
Exact Mass: 415.1759
Molecular Weight: 415.46
Elemental Analysis: C, 69.38; H, 5.82; F, 13.72; N, 3.37; O, 7.70
The following data is based on the product molecular weight 415.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
