Synonym
Pyrathiazine; Parathiazinum; Parathiazine; Paratiazina
IUPAC/Chemical Name
Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-
InChi Key
KJKJUXGEMYCCJN-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H20N2S/c1-3-9-17-15(7-1)20(14-13-19-11-5-6-12-19)16-8-2-4-10-18(16)21-17/h1-4,7-10H,5-6,11-14H2
SMILES Code
C12=CC=CC=C1N(CCN3CCCC3)C4=C(C=CC=C4)S2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
296.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: PYRATHIAZINE hydrochloride. J Am Med Assoc. 1956 Aug 4;161(14):1384. PMID: 13331807.
2: Wrenn TR, Bitman J, Wood JR. Uterine deciduoma induction: comparison of direct mechanical trauma with systemic pyrathiazine. J Endocrinol. 1967 Mar;37(3):289-96. doi: 10.1677/joe.0.0370289. PMID: 4381300.
3: MARCUS GJ, KRAICER PF, SHELESNYAK MC. Studies on the mechanism of decidualization. II. Histamine-releasing action of pyrathiazine. J Reprod Fertil. 1963 Jun;5:409-15. doi: 10.1530/jrf.0.0050409. PMID: 13932916.
4: SHELESNYAK MC, KRAICER PF. Pyrathiazine is an antihistaminic capable of inducing uterine deciduomas by liberation of histamine within the body. C R Hebd Seances Acad Sci. 1959 Apr 6;248(14):2126-8. English, French. PMID: 13652441.
5: BARTLET AL. THE ACTION OF HISTAMINE ON THE ISOLATED HEART. Br J Pharmacol Chemother. 1963 Dec;21(3):450-61. doi: 10.1111/j.1476-5381.1963.tb02013.x. PMID: 14110745; PMCID: PMC1703891.
6: BROWN HW, CHAN KF, YOLKEN H. Efficacy of promethazine and pyrathiazine against enterobiasis. J Am Med Assoc. 1956 Nov 10;162(11):1049-51. doi: 10.1001/jama.1956.72970280001011. PMID: 13366707.
7: Castro-Vázquez A, Gómez E, De Carli DN, Rosner JM. Further evidence for histamine facilitating oestrogen action in the uterus. J Endocrinol. 1976 Jan;68(1):121-6. doi: 10.1677/joe.0.0680121. PMID: 3616.
8: Barkai U, Kidron T, Kraicer PF. Inhibition of decidual induction in rats by clomiphene and tamoxifen. Biol Reprod. 1992 Apr;46(4):733-9. doi: 10.1095/biolreprod46.4.733. PMID: 1576272.
9: Vladimirsky F, Chen L, Amsterdam A, Zor U, Lindner HR. Differentiation of decidual cells in cultures of rat endometrium. J Reprod Fertil. 1977 Jan;49(1):61-8. doi: 10.1530/jrf.0.0490061. PMID: 833790.
10: DELMAS-MARSALET P, FAURE J, ARNE L. Mécanisme d'action du diéthylamino- éthyl-N-dibenzo-parathiazine sur l'hypertonie extrapyramidale [Mechanism of action of diethylamino-ethyl-N-dibenzo-parathiazine on extrapyramidal hypertonia]. C R Seances Soc Biol Fil. 1950 Sep;144(17-18):1163-5. Undetermined Language. PMID: 14801876.
