MedKoo Cat#: 414737 | Name: Palbinone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Palbinone is a terpenoid isolated from the roots of Paeonia albiflora; showed strong inhibitory activity against 3-alpha-hydroxysteroid dehydrogenase.

Chemical Structure

Palbinone
Palbinone
CAS#139954-00-0

Theoretical Analysis

MedKoo Cat#: 414737

Name: Palbinone

CAS#: 139954-00-0

Chemical Formula: C22H30O4

Exact Mass: 358.2144

Molecular Weight: 358.48

Elemental Analysis: C, 73.71; H, 8.44; O, 17.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Palbinone
IUPAC/Chemical Name
18-Norandrosta-11,13(17)-diene-15,16-dione, 3,17-dihydroxy-4,4,8,14-tetramethyl-, (3beta,5alpha)-
InChi Key
KIAKLFLISZCITK-PPAUHQMUSA-N
InChi Code
InChI=1S/C22H30O4/c1-19(2)13-8-11-21(4)14(20(13,3)10-9-15(19)23)7-6-12-16(24)17(25)18(26)22(12,21)5/h6-7,13-15,23-24H,8-11H2,1-5H3/t13-,14+,15-,20-,21+,22-/m0/s1
SMILES Code
C[C@@]1(CC[C@H](O)C(C)(C)[C@]1([H])CC[C@@]2(C)[C@]3(C)C4=O)[C@@]2([H])C=CC3=C(O)C4=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 358.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shi Q, Wang J, Cheng Y, Dong X, Zhang M, Pei C. Palbinone alleviates diabetic retinopathy in STZ-induced rats by inhibiting NLRP3 inflammatory activity. J Biochem Mol Toxicol. 2020 Jul;34(7):e22489. doi: 10.1002/jbt.22489. Epub 2020 Mar 22. PMID: 32202043. 2: Ha do T, Phuong TT, Oh J, Bae K, Thuan ND, Na M. Palbinone from Paeonia suffruticosa protects hepatic cells via up-regulation of heme oxygenase-1. Phytother Res. 2014 Feb;28(2):308-11. doi: 10.1002/ptr.4993. Epub 2013 Apr 18. PMID: 23595773. 3: Kadota S, Terashima S, Basnet P, Kikuchi T, Namba T. Palbinone, a novel terpenoid from Paeonia albiflora; potent inhibitory activity on 3 alpha- hydroxysteroid dehydrogenase. Chem Pharm Bull (Tokyo). 1993 Mar;41(3):487-90. doi: 10.1248/cpb.41.487. PMID: 8477499. 4: Ha do T, Tuan DT, Thu NB, Nhiem NX, Ngoc TM, Yim N, Bae K. Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin- resistant human HepG2 Cells. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5556-9. doi: 10.1016/j.bmcl.2009.08.048. Epub 2009 Aug 15. PMID: 19716700. 5: Du W, Liang X, Wang S, Lee P, Zhang Y. The Underlying Mechanism of Paeonia lactiflora Pall. in Parkinson's Disease Based on a Network Pharmacology Approach. Front Pharmacol. 2020 Nov 23;11:581984. doi: 10.3389/fphar.2020.581984. PMID: 33381034; PMCID: PMC7768820. 6: Zhang JF, Li YC, Song YQ, Xia GY, Xia H, Wang YN, Tian GH, Ge GB, Lin S. Paeonone A, a novel nonanortriterpenoid from the roots of Paeonia lactiflora. Bioorg Chem. 2021 May;110:104783. doi: 10.1016/j.bioorg.2021.104783. Epub 2021 Mar 2. PMID: 33714021.