UU-T02 | CAS#1500080-17-0

MedKoo Cat#: 555465 | Name: UU-T02

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UU-T02 is a potent, selective small-molecule inhibitor of β-catenin/Tcf4 interaction. The β-catenin/T-cell factor (Tcf) protein−protein interaction (PPI) plays a critical role in the β-catenin signaling pathway which is hyperactivated in many cancers and fibroses. UU-T02 disrupted β-catenin/Tcf PPI with a Ki of 1.36 μM in the fluorescence polarization (FP) competitive inhibition assay and displayed 175- and 64-fold selectivity over β-catenin/E-cadherin and β-catenin/APC, respectively.

Chemical Structure

UU-T02

CAS#1500080-17-0

Theoretical Analysis

MedKoo Cat#: 555465

Name: UU-T02

CAS#: 1500080-17-0

Chemical Formula: C33H33ClN4O9

Exact Mass: 664.1936

Molecular Weight: 665.10

Elemental Analysis: C, 59.59; H, 5.00; Cl, 5.33; N, 8.42; O, 21.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

UU-T02; UU-T-02; UU-T 02; UUT02; UUT-02; UUT 02;

IUPAC/Chemical Name

(S)-4-((S)-3-carboxy-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)propanamido)-5-methoxy-5-oxopentanoic acid

InChi Key

SGTICZUBRHDIMI-QKDODKLFSA-N

InChi Code

InChI=1S/C33H33ClN4O9/c1-47-33(46)25(10-11-29(40)41)37-32(45)27(17-30(42)43)38-31(44)26(13-18-6-7-19-4-2-3-5-20(19)12-18)36-28(39)16-23-15-21-14-22(34)8-9-24(21)35-23/h2-9,12,14-15,25-27,35H,10-11,13,16-17H2,1H3,(H,36,39)(H,37,45)(H,38,44)(H,40,41)(H,42,43)/t25-,26-,27-/m0/s1

SMILES Code

O=C(O)CC[C@H](NC([C@@H](NC([C@@H](NC(CC(N1)=CC2=C1C=CC(Cl)=C2)=O)CC3=CC=C4C=CC=CC4=C3)=O)CC(O)=O)=O)C(OC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 665.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Optimization of Peptidomimetics as Selective Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction Zhen Wang, Min Zhang, Jin Wang, and Haitao Ji Publication Date (Web): March 11, 2019 (Article) DOI: 10.1021/acs.jmedchem.9b00147