MedKoo Cat#: 414694 | Name: Oxprenoate potassium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxprenoate potassium is a synthetic steroidal antimineralocorticoid which was never marketed. The affinities of oxprenoate potassium for the steroid hormone receptors have been reported. Mineralocorticoid receptor (MR) antagonism with oxprenoate potassium inhibited aldosterone-induced increases in galectin-3 in primary rat aortic vascular smooth muscle cells, but these compounds had no effect on galectin-3 concentrations in the absence of aldosterone.

Chemical Structure

Oxprenoate potassium
Oxprenoate potassium
CAS#76676-34-1 (K+)

Theoretical Analysis

MedKoo Cat#: 414694

Name: Oxprenoate potassium

CAS#: 76676-34-1 (K+)

Chemical Formula: C25H37KO4

Exact Mass: 440.2329

Molecular Weight: 440.67

Elemental Analysis: C, 68.14; H, 8.46; K, 8.87; O, 14.52

Price and Availability

Size Price Availability Quantity
5mg USD 385.00 2 Weeks
10mg USD 700.00 2 Weeks
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Related CAS #
786592-95-8 (free base); 76676-34-1 (K+)
Synonym
Oxprenoate potassium; RU28318; RU-28318; RU 28318
IUPAC/Chemical Name
Potassium 17-hydroxy-3-oxo-7alpha-propyl-17alpha-pregn-4-ene-21-carboxylate
InChi Key
HXJITUGMCJCKCE-NKTBGYRQSA-M
InChi Code
InChI=1S/C25H38O4.K/c1-4-5-16-14-17-15-18(26)6-10-23(17,2)19-7-11-24(3)20(22(16)19)8-12-25(24,29)13-9-21(27)28;/h15-16,19-20,22,29H,4-14H2,1-3H3,(H,27,28);/q;+1/p-1/t16-,19+,20+,22-,23+,24+,25+;/m1./s1
SMILES Code
C[C@@]12[C@](CCC([O-])=O)(O)CC[C@@]1([H])[C@]3([H])[C@H](CCC)CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O.[K+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Crochemore C, Lu J, Wu Y, Liposits Z, Sousa N, Holsboer F, Almeida OF. Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry. 2005 Aug;10(8):790-8. doi: 10.1038/sj.mp.4001679. PMID: 15940303. 2: Edelmann, F., Holzendorf, V., Wachter, R., Nolte, K., Schmidt, A. G., Kraigher‐Krainer, E., ... & Pieske, B. M. (2015). Galectin‐3 in patients with heart failure with preserved ejection fraction: results from the Aldo‐DHF trial. European journal of heart failure, 17(2), 214-223.