Antagonist G is a neuropeptide antagonist. It inhibits the binding of vasopressin to rat liver or Swiss 3T3 membranes (IC50s = 3.5 and 2.2 µM, respectively) and vasopressin-induced production of inositol phosphate in Swiss 3T3 fibroblasts (IC50 = 1 µM). Antagonist G (50 µM) induces apoptosis and the production of reactive oxygen species (ROS) in NCI H69 small cell lung cancer (SCLC) cells. It reduces tumor growth in an NCI H69 mouse xenograft model when administered at a dose of 45 µg/g.
MedKoo Cat#: 465285
Name: Antagonist G TFA
CAS#: Antagonist G TFA
Chemical Formula: C51H67F3N12O8S
Exact Mass: 1064.4878
Molecular Weight: 1065.23
Elemental Analysis: C, 57.51; H, 6.34; F, 5.35; N, 15.78; O, 12.02; S, 3.01
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 30.0 | 28.16 | ||
| DMSO | 30.0 | 28.16 | ||
| DMSO:PBS (pH 7.2) (1:3) | 0.3 | 0.23 | ||
| Ethanol | 20.0 | 18.78 |
The following data is based on the product molecular weight 1,065.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
