Osemozotan Free Base | CAS# 137275-81-1 (free base) | 5-HT(1A) receptor agonist

MedKoo Cat#: 414641 | Name: Osemozotan Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Osemozotan Free Base is a 5-HT(1A) receptor agonist.

Chemical Structure

Osemozotan Free Base

CAS#137275-81-1 (free base)

Theoretical Analysis

MedKoo Cat#: 414641

Name: Osemozotan Free Base

CAS#: 137275-81-1 (free base)

Chemical Formula: C19H21NO5

Exact Mass: 343.1420

Molecular Weight: 343.38

Elemental Analysis: C, 66.46; H, 6.16; N, 4.08; O, 23.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

137275-81-1 (free base) 137275-80-0 (HCl)

Synonym

Osemozotan Free Base

IUPAC/Chemical Name

3-(1,3-Benzodioxol-5-yloxy)-N-(((2S)-2,3-dihydro-1,4-benzodioxin-2-yl)methyl)propan-1-amine

InChi Key

MEEQBDCQPIZMLY-HNNXBMFYSA-N

InChi Code

InChI=1S/C19H21NO5/c1-2-5-18-16(4-1)22-12-15(25-18)11-20-8-3-9-21-14-6-7-17-19(10-14)24-13-23-17/h1-2,4-7,10,15,20H,3,8-9,11-13H2/t15-/m0/s1

SMILES Code

[C@@H]1(CNCCCOC2=CC=C(OCO3)C3=C2)OC4=CC=CC=C4OC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 343.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Matsuda T. Neuropharmacologic studies on the brain serotonin1A receptor using the selective agonist osemozotan. Biol Pharm Bull. 2013;36(12):1871-82. doi: 10.1248/bpb.b13-00645. PMID: 24292048. 2: Tsuchida R, Kubo M, Kuroda M, Shibasaki Y, Shintani N, Abe M, Köves K, Hashimoto H, Baba A. An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice. J Pharmacol Sci. 2009 Mar;109(3):396-402. doi: 10.1254/jphs.08297fp. Epub 2009 Mar 7. PMID: 19270432. 3: Ago Y, Nakamura S, Hayashi A, Itoh S, Baba A, Matsuda T. Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice. Pharmacol Biochem Behav. 2006 Sep;85(1):198-205. doi: 10.1016/j.pbb.2006.07.036. Epub 2006 Sep 8. PMID: 16962650. 4: Ago Y, Nakamura S, Uda M, Kajii Y, Abe M, Baba A, Matsuda T. Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice. Neuropharmacology. 2006 Sep;51(4):914-22. doi: 10.1016/j.neuropharm.2006.06.001. Epub 2006 Jul 24. PMID: 16863654. 5: Tsuchida R, Kubo M, Shintani N, Abe M, Köves K, Uetsuki K, Kuroda M, Hashimoto H, Baba A. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. doi: 10.1248/bpb.32.728. PMID: 19336914. 6: Ago Y, Nakamura S, Baba A, Matsuda T. Neuropsychotoxicity of abused drugs: effects of serotonin receptor ligands on methamphetamine- and cocaine-induced behavioral sensitization in mice. J Pharmacol Sci. 2008 Jan;106(1):15-21. doi: 10.1254/jphs.fm0070121. Epub 2008 Jan 16. PMID: 18198473. 7: Hiramatsu N, Ago Y, Hasebe S, Nishimura A, Mori K, Takuma K, Matsuda T. Synergistic effect of 5-HT1A and σ1 receptor activation on prefrontal dopaminergic transmission under circulating steroid deficiency. Neuropharmacology. 2013 Dec;75:53-61. doi: 10.1016/j.neuropharm.2013.06.026. Epub 2013 Jul 9. PMID: 23851260. 8: Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T. Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. Psychopharmacology (Berl). 2016 Sep;233(17):3125-34. doi: 10.1007/s00213-016-4353-3. Epub 2016 Jun 23. PMID: 27339616. 9: Tanaka T, Ago Y, Umehara C, Imoto E, Hasebe S, Hashimoto H, Takuma K, Matsuda T. Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice. Int J Neuropsychopharmacol. 2017 May 1;20(5):410-421. doi: 10.1093/ijnp/pyw115. PMID: 28034961; PMCID: PMC5417057. 10: Nakamura S, Ago Y, Hayashi A, Itoh S, Kakuda M, Hashimoto H, Baba A, Matsuda T. Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. Synapse. 2006 Dec 1;60(7):479-84. doi: 10.1002/syn.20323. PMID: 16952156.