Osemozotan hydrochloride | CAS#137275-81-1 | 137275-80-0 | 5-HT1A receptor agonist

MedKoo Cat#: 326951 | Name: Osemozotan HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Osemozotan, also known as MCI-242; MKC-242; MN-305, 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder. Osemozotan is being investigated in its usage to treat pain, aggressive behavior, anxiety, depression, obsessive-compulsive disorder, and drug dependence with methamphetamine and cocaine.

Chemical Structure

Osemozotan HCl

CAS#137275-80-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 326951

Name: Osemozotan HCl

CAS#: 137275-80-0 (HCl)

Chemical Formula: C19H22ClNO5

Exact Mass:

Molecular Weight: 379.84

Elemental Analysis: C, 60.08; H, 5.84; Cl, 9.33; N, 3.69; O, 21.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

137275-81-1 (free base) 137275-80-0 (HCl)

Synonym

Osemozotan hydrochloride; MCI-242; MKC-242; MN-305; MCI242; MKC242; MN305.

IUPAC/Chemical Name

5-(3-((2S)-(1,4-Benzodioxan-2-ylmethyl)amino)propoxy)-1,3-benzodioxol hydrochloride

InChi Key

GGNCUSDIUUCNKE-RSAXXLAASA-N

InChi Code

InChI=1S/C19H21NO5.ClH/c1-2-5-18-16(4-1)22-12-15(25-18)11-20-8-3-9-21-14-6-7-17-19(10-14)24-13-23-17;/h1-2,4-7,10,15,20H,3,8-9,11-13H2;1H/t15-;/m0./s1

SMILES Code

[H]Cl.C12=CC(OCCCNC[C@@H]3OC4=CC=CC=C4OC3)=CC=C1OCO2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 137275-81-1(Osemozotan free base) 137275-80-0 (Osemozotan hydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 379.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Matsuda T. Neuropharmacologic studies on the brain serotonin1A receptor using the selective agonist osemozotan. Biol Pharm Bull. 2013;36(12):1871-82. Review. PubMed PMID: 24292048. 2: Tsuchida R, Kubo M, Shintani N, Abe M, Köves K, Uetsuki K, Kuroda M, Hashimoto H, Baba A. Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. Biol Pharm Bull. 2009 Apr;32(4):728-31. PubMed PMID: 19336914. 3: Tsuchida R, Kubo M, Kuroda M, Shibasaki Y, Shintani N, Abe M, Köves K, Hashimoto H, Baba A. An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice. J Pharmacol Sci. 2009 Mar;109(3):396-402. Epub 2009 Mar 7. PubMed PMID: 19270432. 4: Ago Y, Nakamura S, Hayashi A, Itoh S, Baba A, Matsuda T. Effects of osemozotan, ritanserin and azasetron on cocaine-induced behavioral sensitization in mice. Pharmacol Biochem Behav. 2006 Sep;85(1):198-205. Epub 2006 Sep 8. PubMed PMID: 16962650. 5: Ago Y, Nakamura S, Uda M, Kajii Y, Abe M, Baba A, Matsuda T. Attenuation by the 5-HT1A receptor agonist osemozotan of the behavioral effects of single and repeated methamphetamine in mice. Neuropharmacology. 2006 Sep;51(4):914-22. Epub 2006 Jul 24. PubMed PMID: 16863654.