Synonym
Org GC 94; ORG GC94; ORG GC-94
IUPAC/Chemical Name
1,3,4,14b-Tetrahydro-2,7-dimethyl-2H-dibenzo(b,f)pyrazino(1,2-d)(1,4)oxazepine
InChi Key
AQCUOHAOVDYWGZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H20N2O/c1-13-7-8-18-15(11-13)20-10-9-19(2)12-16(20)14-5-3-4-6-17(14)21-18/h3-8,11,16H,9-10,12H2,1-2H3
SMILES Code
CC1=CC=C2OC3=CC=CC=C3C(CN(C)CC4)N4C2=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
280.37
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lamar JC, Hardebo JE. Interaction of a potential antimigraine drug (Org GC 94) with the vasomotor action of serotonin. Eur J Pharmacol. 1979 Dec 20;60(4):263-75. doi: 10.1016/0014-2999(79)90230-9. PMID: 527662.
2: Kopera H, Schenk H, Voerman JW. The effect of Org GC 94 on thrombocyte function, blood coagulation and the fibrinolytic system in man. Int J Clin Pharmacol Biopharm. 1978 Nov;16(11):529-32. PMID: 730419.
3: Bhargava N, Matthijsen R, Schönbaum E. Some effects of ORG GC 94, a potential anti-migraine drug, on human platelets. Eur J Pharmacol. 1977 Apr 7;42(3):241-5. doi: 10.1016/0014-2999(77)90290-4. PMID: 852500.
4: de Ridder JJ, van Hal HJ. Unexpected high-performance liquid chromatographic separation of Org GC 94 and [3, 3, 4, 4-2H4] Org GC 94. J Chromatogr. 1976 Jun 9;121(1):96-9. doi: 10.1016/s0021-9673(00)82306-7. PMID: 932141.
5: Sulman FG, Pfeifer Y, Superstine E. Preventive treatment of serotonin- migraine with 1,3,4,14b-tetrahydro-2,7-dimethyl-2H-dibenzo(b,f)pyrazino-(1,2-- d)-(1,4)-oxazepine hydrogen maleate (Org GC 94). A double-blind study. Arzneimittelforschung. 1981;31(1):109-12. PMID: 7011331.
6: Harper B, Hughes IE. Presynaptic alpha-adrenoceptor blocking properties among tri- and tetra-cyclic antidepressant drugs. Br J Pharmacol. 1979 Dec;67(4):511-7. doi: 10.1111/j.1476-5381.1979.tb08696.x. PMID: 42458; PMCID: PMC2043908.
7: Sandker GW, Vos RM, Delbressine LP, Slooff MJ, Meijer DK, Groothuis GM. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo. Xenobiotica. 1994 Feb;24(2):143-55. doi: 10.3109/00498259409043228. PMID: 8017089.
8: Hoekstra A, Yih TD, Joosten HF, Waalkens DH. The effects of chlorpromazine, mianserin and Org GC94 on reproductive function in the rat. Drug Chem Toxicol. 1984;7(1):11-22. doi: 10.3109/01480548409014170. PMID: 6539196.
9: Riley RJ, Roberts P, Kitteringham NR, Park BK. Formation of cytotoxic metabolites from phenytoin, imipramine, desipramine, amitriptyline and mianserin by mouse and human hepatic microsomes. Biochem Pharmacol. 1990 Jun 15;39(12):1951-8. doi: 10.1016/0006-2952(90)90614-q. PMID: 2353936.
10: Anselmi B, Del Bianco PL, de Vos CJ, Galli P, Lamar JC, Schönbaum E, Sicuteri F, van der Veen F. Clinical and animal pharmacology of migraine: new perspectives. Monogr Neural Sci. 1976;3:45-59. doi: 10.1159/000399334. PMID: 979997.
