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MedKoo Cat#: 465268 | Name: SLU-2633

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLU-2633 is an anticryptosporidial agent. SLU-2633 has an EC50 of 0.17 μM, an improved projected margin versus hERG, prolonged pharmacokinetic exposure in small intestine, and oral efficacy in vivo with minimal systemic exposure. SLU-2633 represents a significant advancement toward the identification of a new effective and safe treatment for cryptosporidiosis.

Chemical Structure

SLU-2633
SLU-2633
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465268

Name: SLU-2633

CAS#: unknown

Chemical Formula: C17H16Cl2N6O

Exact Mass: 390.0763

Molecular Weight: 391.26

Elemental Analysis: C, 52.19; H, 4.12; Cl, 18.12; N, 21.48; O, 4.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SLU-2633; SLU2633; SLU 2633;
IUPAC/Chemical Name
1-(4-([1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperazin-1-yl)-2-(3,4-dichlorophenyl)ethan-1-one
InChi Key
OVJKTOJIQGHSQP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H16Cl2N6O/c18-13-2-1-12(9-14(13)19)10-17(26)24-7-5-23(6-8-24)16-4-3-15-21-20-11-25(15)22-16/h1-4,9,11H,5-8,10H2
SMILES Code
O=C(N1CCN(C2=NN3C(C=C2)=NN=C3)CC1)CC4=CC=C(Cl)C(Cl)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Oboh E, Schubert TJ, Teixeira JE, Stebbins EE, Miller P, Philo E, Thakellapalli H, Campbell SD, Griggs DW, Huston CD, Meyers MJ. Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin. J Med Chem. 2021 Aug 3. doi: 10.1021/acs.jmedchem.1c01136. Epub ahead of print. PMID: 34342443.