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MedKoo Cat#: 465338 | Name: SLL-1206

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SLL-1206 is a Selective, Potent, and Orally Active κ‑Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile. SLL-1206 exhibited substantially improved physicochemical and pharmacokinetic properties compared with SLL-039, with increases of over 20-fold in aqueous solubility and approximately 40-fold in oral bioavailability in rats.

Chemical Structure

SLL-1206
SLL-1206
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465338

Name: SLL-1206

CAS#: unknown

Chemical Formula: C38H44N2O4

Exact Mass: 592.3301

Molecular Weight: 592.78

Elemental Analysis: C, 77.00; H, 7.48; N, 4.73; O, 10.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SLL-1206; SLL1206; SLL 1206;
IUPAC/Chemical Name
3-((4R,4aS,6R,7R,7aR,12bS)-3-(cyclopropylmethyl)-7,9-dimethoxy-1,2,3,4,5,6,7,7a-octahydro-4a,7-ethano-4,12-methanobenzofuro[3,2-e]isoquinolin-6-yl)-N-(4-methoxybenzyl)aniline
InChi Key
WSYLBNPTBTYVDS-JDHNVOLOSA-N
InChi Code
InChI=1S/C38H44N2O4/c1-41-29-12-9-24(10-13-29)22-39-28-6-4-5-26(19-28)30-21-36-15-16-38(30,43-3)35-37(36)17-18-40(23-25-7-8-25)32(36)20-27-11-14-31(42-2)34(44-35)33(27)37/h4-6,9-14,19,25,30,32,35,39H,7-8,15-18,20-23H2,1-3H3/t30-,32-,35-,36-,37+,38?/m1/s1
SMILES Code
COC(C=C1)=CC=C1CNC2=CC=CC([C@@H]3[C@@]4(OC)[C@H]5[C@]6(CCN7CC8CC8)C9=C(O5)C(OC)=CC=C9C[C@@H]7[C@@]6(CC4)C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 592.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: He Q, Wei Y, Liu X, Ye R, Kong L, Li Z, Jiang S, Yu L, Chai J, Xie Q, Fu W, Wang Y, Li W, Qiu Z, Liu J, Shao L. Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile. J Med Chem. 2021 Aug 13. doi: 10.1021/acs.jmedchem.1c01082. Epub ahead of print. PMID: 34387468.