MedKoo Cat#: 577179 | Name: Mesoridazine hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mesoridazine hydrochloride is a phenothiazine antipsychotic with effects similar to chlorpromazine.

Chemical Structure

Mesoridazine hydrochloride
CAS#59884-26-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 577179

Name: Mesoridazine hydrochloride

CAS#: 59884-26-3 (HCl)

Chemical Formula: C21H27ClN2OS2

Exact Mass: 422.1253

Molecular Weight: 423.03

Elemental Analysis: C, 59.62; H, 6.43; Cl, 8.38; N, 6.62; O, 3.78; S, 15.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Mesoridazine hydrochloride; Mesoridazine HCl
IUPAC/Chemical Name
10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfinyl)-, monohydrochloride
InChi Key
IXTOSJVLICGBLQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H26N2OS2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(26(2)24)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
SMILES Code
Cl.CN1CCCCC1CCN2c3ccccc3Sc4ccc(cc24)S(=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 423.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Im SH, Park MJ, Seo H, Choi SH, Kim SK, Ahn SH. Determination of mesoridazine by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 May 1;958:117-23. doi: 10.1016/j.jchromb.2014.03.020. Epub 2014 Mar 24. PubMed PMID: 24732149. 2: Liu KS, Chen YW, Aljuffali IA, Chang CW, Wang JJ, Fang JY. Topically applied mesoridazine exhibits the strongest cutaneous analgesia and minimized skin disruption among tricyclic antidepressants: The skin absorption assessment. Eur J Pharm Biopharm. 2016 Aug;105:59-68. doi: 10.1016/j.ejpb.2016.05.025. Epub 2016 May 31. PubMed PMID: 27260201. 3: Salih IS, Thanacoody RH, McKay GA, Thomas SH. Comparison of the effects of thioridazine and mesoridazine on the QT interval in healthy adults after single oral doses. Clin Pharmacol Ther. 2007 Nov;82(5):548-54. Epub 2007 Apr 4. PubMed PMID: 17410120. 4: Charalampous KD, Johnson PC, Estevez V. Absorption and excretion of thioridazine and mesoridazine in man. Dis Nerv Syst. 1974 Nov;35(11):494-6. PubMed PMID: 17896456. 5: Gershon S, Sakalis G, Bowers PA. Mesoridazine -- a pharmacodynamic and pharmacokinetic profile. J Clin Psychiatry. 1981 Dec;42(12):463-9. Review. PubMed PMID: 7031039.