MedKoo Cat#: 564887 | Name: MET-IN-3S

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MET-IN-3S is a highly selective class II MET inhibitor.

Chemical Structure

MET-IN-3S
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564887

Name: MET-IN-3S

CAS#: NONE

Chemical Formula: C25H19F2IN4O4

Exact Mass: 604.0419

Molecular Weight: 604.35

Elemental Analysis: C, 49.69; H, 3.17; F, 6.29; I, 21.00; N, 9.27; O, 10.59

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
METIN-3S; MET-IN3S; MET IN-3S; MET-IN 3S; METIN3S; MET IN 3S; MET-IN-3S
IUPAC/Chemical Name
1-(4-((2-Amino-3-iodopyridin-4-yl)-oxy)-3-fluorophenyl)-N-(4-fluorobenzyl)-4-methoxy-6-oxo-1,6-dihydropyridine-3-carboxamide
InChi Key
BLNJAGORPQMNJY-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H19F2IN4O4/c1-35-21-11-22(33)32(13-17(21)25(34)31-12-14-2-4-15(26)5-3-14)16-6-7-19(18(27)10-16)36-20-8-9-30-24(29)23(20)28/h2-11,13H,12H2,1H3,(H2,29,30)(H,31,34)
SMILES Code
O=C(C(C(OC)=C1)=CN(C2=CC=C(OC3=C(I)C(N)=NC=C3)C(F)=C2)C1=O)NCC4=CC=C(F)C=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 604.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xu YC, Wang X, Chen Y, Chen SM, Yang XY, Sun YM, Geng MY, Ding J, Meng LH. Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast Cancer. Theranostics. 2017 Feb 23;7(4):974-986. doi: 10.7150/thno.17830. eCollection 2017. PubMed PMID: 28382169; PubMed Central PMCID: PMC5381259. 2: She N, Zhuo L, Jiang W, Zhu X, Wang J, Ming Z, Zhao X, Cong X, Huang W. Design, synthesis and evaluation of highly selective pyridone-based class II MET inhibitors. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3351-5. doi: 10.1016/j.bmcl.2014.05.097. Epub 2014 Jun 6. PubMed PMID: 24951334.