Synonym
Org 31806; Org31806; Org-31806
IUPAC/Chemical Name
Spiro(estra-4,9-diene-17,2'(3'H)-furan)-3-one, 11-(4-(dimethylamino)phenyl)-4',5'-dihydro-7-methyl-, (7beta,11beta,17beta)-
InChi Key
WFPOBMHQGIPWFB-GCLUAJDJSA-N
InChi Code
InChI=1S/C30H39NO2/c1-19-16-21-17-23(32)10-11-24(21)28-25(20-6-8-22(9-7-20)31(3)4)18-29(2)26(27(19)28)12-14-30(29)13-5-15-33-30/h6-9,17,19,25-27H,5,10-16,18H2,1-4H3/t19-,25+,26-,27-,29-,30-/m0/s1
SMILES Code
C[C@@]12[C@@]3(OCCC3)CC[C@@]1([H])[C@]4([H])[C@@H](C)CC5=CC(CCC5=C4[C@@H](C6=CC=C(N(C)C)C=C6)C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
445.65
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kloosterboer HJ, Deckers GH, Schoonen WG. Pharmacology of two new very selective antiprogestagens: Org 31710 and Org 31806. Hum Reprod. 1994 Jun;9 Suppl 1:47-52. doi: 10.1093/humrep/9.suppl_1.47. PMID: 7962469.
2: Skinner DC. Org-31806 Organon NV. IDrugs. 1998 Jul;1(3):350-4. PMID: 18465560.
3: Dao B, Vanage G, Li XJ, Bardin CW, Koide SS. Comparative effectiveness of three antiprogestins alone and in combination with anordiol in terminating pregnancy in the rat. Contraception. 1997 Jan;55(1):35-40. doi: 10.1016/s0010-7824(96)00239-9. PMID: 9013059.
4: Mizutani T, Bhakta A, Kloosterboer HJ, Moudgil VK. Novel antiprogestins Org 31806 and 31710: interaction with mammalian progesterone receptor and DNA binding of antisteroid receptor complexes. J Steroid Biochem Mol Biol. 1992 Aug;42(7):695-704. doi: 10.1016/0960-0760(92)90110-5. PMID: 1504008.
5: Klijn JG, Setyono-Han B, Sander HJ, Lamberts SW, de Jong FH, Deckers GH, Foekens JA. Pre-clinical and clinical treatment of breast cancer with antiprogestins. Hum Reprod. 1994 Jun;9 Suppl 1:181-9. doi: 10.1093/humrep/9.suppl_1.181. PMID: 7962463.
6: Hurd C, Underwood B, Herman M, Iwasaki K, Kloosterboer HJ, Dinda S, Moudgil VK. Characterization of ligand binding, DNA binding and phosphorylation of progesterone receptor by two novel progesterone receptor antagonist ligands. Mol Cell Biochem. 1997 Oct;175(1-2):205-12. doi: 10.1023/a:1006827701940. PMID: 9350053.
7: Xiao E, Xia-Zhang L, Shanen D, Ferin M. Tonic support of luteinizing hormone secretion by adrenal progesterone in the ovariectomized monkey replaced with midfollicular phase levels of estradiol. J Clin Endocrinol Metab. 1997 Jul;82(7):2233-8. doi: 10.1210/jcem.82.7.4083. PMID: 9215299.
8: Iwasaki K, Underwood B, Herman M, Dinda S, Kodali S, Kloosterboer HJ, Hurd C, Moudgil VK. Effects of antiprogestins on the rate of proliferation of breast cancer cells. Mol Cell Biochem. 1999 Aug;198(1-2):141-9. doi: 10.1023/a:1006945813508. PMID: 10497889.
9: Koper JW, Molijn GJ, van Uffelen CJ, Stigter E, Lamberts SW. Antiprogestins and iatrogenic glucocorticoid resistance. Life Sci. 1997;60(9):617-24. doi: 10.1016/s0024-3205(96)00698-4. PMID: 9048964.
10: Bhakta A, Herman M, Levina IS, Moudgil VK. Interaction of cycloalkanoprogesterones with mammalian progesterone receptor: binding of pregna-D'-pentaranes in the calf uterine cytosol. Mol Cell Biochem. 1993 Aug 25;125(2):153-61. doi: 10.1007/BF00936444. PMID: 8283970.
