JHU395 is a novel orally-bioavailable GA prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues.. JHU395 deliverers active GA to tumors with over two-fold higher tumor-to-plasma exposure, and significantly inhibited tumor growth in a murine flank MPNST model without observed toxicity.
MedKoo Cat#: 593165
Name: JHU395
CAS#: 2079938-92-2
Chemical Formula: C22H29N3O7
Exact Mass: 447.2006
Molecular Weight: 447.49
Elemental Analysis: C, 59.05; H, 6.53; N, 9.39; O, 25.03
The following data is based on the product molecular weight 447.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
