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MedKoo Cat#: 465229 | Name: KN2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KN2 is a bivalent CK2 inhibitor. KN2 binds to CK2 with low nanomolar affinity, is cell-permeable, and suppresses the intracellular phosphorylation of typical CK2 substrates. Kinase profiling revealed a high selectivity of KN2 for CK2 and emphasizes the selectivity-promoting potential of the αD pocket.

Chemical Structure

KN2
KN2
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465229

Name: KN2

CAS#: unknown

Chemical Formula: C23H22Br4Cl2N4O2

Exact Mass: 771.7853

Molecular Weight: 776.97

Elemental Analysis: C, 35.56; H, 2.85; Br, 41.14; Cl, 9.13; N, 7.21; O, 4.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KN2; KN 2; KN-2;
IUPAC/Chemical Name
N1-(3,4-dichlorophenethyl)-N4-(4-(4,5,6,7-tetrabromo-1H-benzo[d]imidazol-1-yl)butyl)succinamide
InChi Key
HHGOOXRIHBVNFX-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22Br4Cl2N4O2/c24-18-19(25)21(27)23-22(20(18)26)32-12-33(23)10-2-1-8-30-16(34)5-6-17(35)31-9-7-13-3-4-14(28)15(29)11-13/h3-4,11-12H,1-2,5-10H2,(H,30,34)(H,31,35)
SMILES Code
O=C(NCCC1=CC=C(Cl)C(Cl)=C1)CCC(NCCCCN2C=NC3=C(Br)C(Br)=C(Br)C(Br)=C23)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 776.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lindenblatt D, Applegate V, Nickelsen A, Klußmann M, Neundorf I, Götz C, Jose J, Niefind K. Molecular Plasticity of Crystalline CK2α' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J Med Chem. 2021 Jul 29. doi: 10.1021/acs.jmedchem.1c00063. Epub ahead of print. PMID: 34323071.