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MedKoo Cat#: 535034 | Name: KN 04

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KN 04 is a bioactive chemical.

Chemical Structure

KN 04
KN 04
CAS#129695-80-3

Theoretical Analysis

MedKoo Cat#: 535034

Name: KN 04

CAS#: 129695-80-3

Chemical Formula: C37H35N5O5S2

Exact Mass: 693.2080

Molecular Weight: 693.84

Elemental Analysis: C, 64.05; H, 5.08; N, 10.09; O, 11.53; S, 9.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KN 04; KN-04 ;KN04
IUPAC/Chemical Name
5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)amino)-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester
InChi Key
IWWLVIDLFHBQER-UHFFFAOYSA-N
InChi Code
InChI=1S/C37H35N5O5S2/c43-48(44,36-10-4-6-29-25-38-18-16-34(29)36)40-31(27-41-20-22-42(23-21-41)32-8-2-1-3-9-32)24-28-12-14-33(15-13-28)47-49(45,46)37-11-5-7-30-26-39-19-17-35(30)37/h1-19,25-26,31,40H,20-24,27H2
SMILES Code
O=S(C1=CC=CC2=C1C=CN=C2)(OC3=CC=C(CC(NS(=O)(C4=CC=CC5=C4C=CN=C5)=O)CN6CCN(C7=CC=CC=C7)CC6)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 693.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gargett CE, Wiley JS. The isoquinoline derivative KN-62 a potent antagonist of the P2Z-receptor of human lymphocytes. Br J Pharmacol. 1997 Apr;120(8):1483-90. doi: 10.1038/sj.bjp.0701081. PMID: 9113369; PMCID: PMC1564633. 2: Brozinick JT Jr, Reynolds TH, Dean D, Cartee G, Cushman SW. 1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle. Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):533-40. PMID: 10215590; PMCID: PMC1220187. 3: Okazaki K, Ishikawa T, Inui M, Tada M, Goshima K, Okamoto T, Hidaka H. KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes. J Pharmacol Exp Ther. 1994 Sep;270(3):1319-24. PMID: 7932185. 4: Cui ZJ, Hidaka H, Dannies PS. KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells. Biochim Biophys Acta. 1996 Feb 29;1310(3):343-7. doi: 10.1016/0167-4889(95)00170-0. PMID: 8599613. 5: Gunosewoyo H, Coster MJ, Kassiou M. Molecular probes for P2X7 receptor studies. Curr Med Chem. 2007;14(14):1505-23. doi: 10.2174/092986707780831023. PMID: 17584060. 6: Maurer JA, Wenger BW, McKay DB. Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry. J Neurochem. 1996 Jan;66(1):105-13. doi: 10.1046/j.1471-4159.1996.66010105.x. PMID: 8522941. 7: Tsutsui M, Yanagihara N, Fukunaga K, Minami K, Nakashima Y, Kuroiwa A, Miyamoto E, Izumi F. Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase. J Neurochem. 1996 Jun;66(6):2517-22. doi: 10.1046/j.1471-4159.1996.66062517.x. PMID: 8632177. 8: Ishikawa N, Hashiba Y, Hidaka H. Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat. J Pharmacol Exp Ther. 1990 Aug;254(2):598-602. PMID: 2384887. 9: Inagaki N, Suzuki S, Kitai H, Nakatogawa N, Kuji N, Iwahashi K, Yoshimura Y. Effect of KN-62, a selective inhibitor of calmodulin-dependent kinase II, on mouse oocyte activation. J Assist Reprod Genet. 1997 Nov;14(10):609-16. doi: 10.1023/a:1022541020458. PMID: 9447464; PMCID: PMC3454741. 10: Wenham RM, Landt M, Walters SM, Hidaka H, Easom RA. Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin- dependent protein kinase II. Biochem Biophys Res Commun. 1992 Nov 30;189(1):128-33. doi: 10.1016/0006-291x(92)91534-w. PMID: 1333187. 11: Humphreys BD, Virginio C, Surprenant A, Rice J, Dubyak GR. Isoquinolines as antagonists of the P2X7 nucleotide receptor: high selectivity for the human versus rat receptor homologues. Mol Pharmacol. 1998 Jul;54(1):22-32. doi: 10.1124/mol.54.1.22. PMID: 9658186. 12: Fan GH, Wang LZ, Qiu HC, Ma L, Pei G. Inhibition of calcium/calmodulin- dependent protein kinase II in rat hippocampus attenuates morphine tolerance and dependence. Mol Pharmacol. 1999 Jul;56(1):39-45. doi: 10.1124/mol.56.1.39. PMID: 10385682. 13: Nishijima KA, Wall MM, Siderhurst MS. Demonstrating Pathogenicity of Enterobacter cloacae on Macadamia and Identifying Associated Volatiles of Gray Kernel of Macadamia in Hawaii. Plant Dis. 2007 Oct;91(10):1221-1228. doi: 10.1094/PDIS-91-10-1221. PMID: 30780515. 14: Wang X, Yu G, Hou X, Zhou J, Yang B, Zhang L. Rebound bursts in GABAergic neurons of the thalamic reticular nucleus in postnatal mice. Physiol Res. 2010;59(2):273-80. Epub 2009 Jun 19. PMID: 19537935. 15: Kubota M, Narita K, Murayama T, Suzuki S, Soga S, Usukura J, Ogawa Y, Kuba K. Type-3 ryanodine receptor involved in Ca2+-induced Ca2+ release and transmitter exocytosis at frog motor nerve terminals. Cell Calcium. 2005 Dec;38(6):557-67. doi: 10.1016/j.ceca.2005.07.008. Epub 2005 Sep 12. PMID: 16157373. 16: Chang MC, Khanna R, Schlichter LC. Regulation of Kv1.3 channels in activated human T lymphocytes by Ca(2+)-dependent pathways. Cell Physiol Biochem. 2001;11(3):123-34. doi: 10.1159/000047800. PMID: 11410708. 17: Noronha KF, Mercier AJ. A role for calcium/calmodulin-dependent protein kinase in mediating synaptic modulation by a neuropeptide. Brain Res. 1995 Feb 27;673(1):70-4. doi: 10.1016/0006-8993(94)01396-y. PMID: 7757481. 18: Ridley DL, Rogers A, Wonnacott S. Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells. Br J Pharmacol. 2001 Aug;133(8):1286-95. doi: 10.1038/sj.bjp.0704207. PMID: 11498514; PMCID: PMC1621156. 19: Satoh R, Nakabayashi Y, Kano M. Ca2+/calmodulin-dependent regulation of the density of Na+ channels in embryonic chick skeletal muscle cells during their development in culture. Biochem Biophys Res Commun. 1994 Sep 15;203(2):852-6. doi: 10.1006/bbrc.1994.2261. PMID: 8093067. 20: Hishinuma S, Ogura K. Ca(2+)/calmodulin-mediated regulation of the desensitizing process in G(q) protein-coupled histamine H(1) receptor-mediated Ca(2+) responses in human U373 MG astrocytoma cells. J Neurochem. 2000 Aug;75(2):772-81. doi: 10.1046/j.1471-4159.2000.0750772.x. PMID: 10899954.

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