Olcorolimus | CAS# 186752-78-3 | inhibits single allergen-induced allergic inflammation

MedKoo Cat#: 414561 | Name: Olcorolimus

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5

Chemical Structure

Olcorolimus

CAS#186752-78-3

Theoretical Analysis

MedKoo Cat#: 414561

Name: Olcorolimus

CAS#: 186752-78-3

Chemical Formula: C51H81NO12

Exact Mass: 899.5759

Molecular Weight: 900.20

Elemental Analysis: C, 68.05; H, 9.07; N, 1.56; O, 21.33

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Olcorolimus; SAR943; SAR943-NXA; SAR943N

IUPAC/Chemical Name

UNKNOWN

InChi Key

QFMKPDZCOKCBAQ-NFCVMBANSA-N

InChi Code

InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1

SMILES Code

CO[C@@H]1C[C@@H](CC[C@H]1O)C[C@H]([C@@H]2CC[C@@H](/C=C([C@H]([C@H](C([C@@H](C[C@@H](/C=C/C=C/C=C([C@@H](OC)C[C@@H]3CC[C@H]([C@@](O3)(C(C(N4CCCC[C@H]4C(O2)=O)=O)=O)O)C)\C)C)C)=O)OC)O)\C)C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 900.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Eynott PR, Salmon M, Huang TJ, Oates T, Nicklin PL, Chung KF. Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats. Immunology. 2003 Jul;109(3):461-7. doi: 10.1046/j.1365-2567.2003.01672.x. PMID: 12807493; PMCID: PMC1782985. 2: Huang TJ, Eynott P, Salmon M, Nicklin PL, Chung KF. Effect of topical immunomodulators on acute allergic inflammation and bronchial hyperresponsiveness in sensitised rats. Eur J Pharmacol. 2002 Feb 22;437(3):187-94. doi: 10.1016/s0014-2999(02)01295-5. PMID: 11890908. 3: Tigani B, Hannon JP, Schaeublin E, Mazzoni L, Fozard JR. Effects of immunomodulators on airways hyperresponsiveness to adenosine induced in actively sensitised Brown Norway rats by exposure to allergen. Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):17-25. doi: 10.1007/s00210-003-0767-7. Epub 2003 Jun 24. PMID: 12827216. 4: Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel HM, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom. 2011 Jul;46(7):615-24. doi: 10.1002/jms.1930. PMID: 21671437.