Synonym
Dicolinium iodide; OF816; OF-816; OF 816
IUPAC/Chemical Name
2-Carboxy-1,1,6-trimethylpiperidinium iodide, ester with diethyl-(2-hydroxyethyl)methylammonium iodide
InChi Key
UHMKISIRZFDJRU-UHFFFAOYSA-L
InChi Code
InChI=1S/C16H34N2O2.2HI/c1-7-18(6,8-2)12-13-20-16(19)15-11-9-10-14(3)17(15,4)5;;/h14-15H,7-13H2,1-6H3;2*1H/q+2;;/p-2
SMILES Code
C[N+](CC)(CC)CCOC(C1[N+](C)(C)C(C)CCC1)=O.[I-].[I-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
540.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Kovalev GI, Rychikhin VM, Kudrin VC, Vasil'eva EV, Kondrakhin EA. [Experimental study of dicholine succinate pharmacokinetics]. Eksp Klin Farmakol. 2014;77(11):23-6. Russian. PMID: 25668944.
2: MCCARTHY JF, CANNON JG, BUCKLEY JP, KINNARD WJ. CYCLIC ANALOGS AND CONGENERS OF SUCCINYL DICHOLINE. J Med Chem. 1964 Jan;7:72-5. doi: 10.1021/jm00331a016. PMID: 14186030.
3: Rychikhin VM, Sariev AK, Pomytkin IA. [Anticonvulsant effect of dicholine succinate on primary generalized epilepsy model in mice]. Eksp Klin Farmakol. 2013;76(3):10-2. Russian. PMID: 23767096.
4: MCCARTHY JF, CANNON JG, BUCKLEY JP. COMPARATIVE ACTIVITIES OF MALEYL, FUMARYL, AND SUCCINYL DICHOLINE. A CORRECTION OF THE LITERATURE. J Pharm Sci. 1963 Dec;52:1168-71. doi: 10.1002/jps.2600521215. PMID: 14088968.
5: Storozheva ZI, Proshin AT, Sherstnev VV, Storozhevykh TP, Senilova YE, Persiyantseva NA, Pinelis VG, Semenova NA, Zakharova EI, Pomytkin IA. Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia. BMC Pharmacol. 2008 Jan 23;8:1. doi: 10.1186/1471-2210-8-1. PMID: 18215309; PMCID: PMC2262060.
6: DARDYMOV IV, RYBOLOVLEV RS. Reflektornaia stimuliatsiia dykhaniia dikholinovym esterom probkovoi kisloty [Reflex stimulation on respiration with dicholine ester of suberic acid]. Biull Eksp Biol Med. 1955 Nov;40(11):41-4. Russian. PMID: 13284050.
7: HERZFELD E, STUMF C. Zur Frage der Cholinesterase-Hemmwirkung der Polymethylen-Dicarbaminsäure-Bischolinester [The anticholinesterase effects of polymethylene-dicarbamic acid dicholine esters]. Arch Int Pharmacodyn Ther. 1955 Jan 1;100(3-4):391-400. German. PMID: 14350859.
8: Iavors'kiĭ MP, Gul'ko RM. Reaktsiï osadzhennia na dykolin [Precipitation reaction of dicolin]. Farm Zh. 1971 Nov-Dec;26(6):31-3. Ukrainian. PMID: 4402548.
9: Guo DS, Zhang TX, Wang YX, Liu Y. Enzyme-responsive supramolecular polymers by complexation of bis(p-sulfonatocalixarenes) with suberyl dicholine-based pseudorotaxane. Chem Commun (Camb). 2013 Aug 4;49(60):6779-81. doi: 10.1039/c3cc41918e. PMID: 23785710.
10: SALLE J. Sur les propriétés du fluorophosphate de dicholine (F.P.D.C.) [The properties of dicholine fluorophosphate]. Arch Int Pharmacodyn Ther. 1953 Aug 1;94(4):483-8. Undetermined Language. PMID: 13114946.
