Tolciclate | CAS#50838-36-3 | antifungal medication

MedKoo Cat#: 558037 | Name: Tolciclate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolciclate is an antifungal medication.

Chemical Structure

Tolciclate

CAS#50838-36-3

Theoretical Analysis

MedKoo Cat#: 558037

Name: Tolciclate

CAS#: 50838-36-3

Chemical Formula: C20H21NOS

Exact Mass: 323.1300

Molecular Weight: 323.45

Elemental Analysis: C, 74.27; H, 6.54; N, 4.33; O, 4.95; S, 9.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tolciclate;

IUPAC/Chemical Name

1,2,3,4-Tetrahydro-1,4-methanonaphthalen-6-yl N-methyl-N-(m-tolyl)carbamothioate

InChi Key

CANCCLAKQQHLNK-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H21NOS/c1-13-4-3-5-16(10-13)21(2)20(23)22-17-8-9-18-14-6-7-15(11-14)19(18)12-17/h3-5,8-10,12,14-15H,6-7,11H2,1-2H3

SMILES Code

S=C(OC1=CC2=C(C3CCC2C3)C=C1)N(C)C4=CC=CC(C)=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 323.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cucè LC, Assunção BF, Medawar LG, Salibian A, Groppi W. Tolciclate versus miconazole, a double-blind trial in patients with dermatomycosis. J Int Med Res. 1980;8(2):144-7. PubMed PMID: 6989684. 2: Qadripur SA. [Antimycotic therapy. 2. Antimycotic chemotherapeutic agents: imidazole derivatives, tolciclate, haloprogin, ciclopiroxolamin]. Fortschr Med. 1983 Mar 10;101(9):355-63. German. PubMed PMID: 6303928. 3: Ryder NS, Frank I, Dupont MC. Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. PubMed PMID: 3524433; PubMed Central PMCID: PMC284167. 4: Wahab S, Srivastava OP, Singh NB, Gupta SK. Comparative in vitro & in vivo evaluation of tolciclate, tolnaftate, miconazole, clotrimazole & undecylenic acid against Trichophyton mentagrophytes. Indian J Exp Biol. 1978 Nov;16(11):1200-2. PubMed PMID: 750408. 5: Pigatto PD, Negri M. [Double-blind evaluation of the antimycotic activity of econazole and tolciclate]. G Ital Dermatol Venereol. 1983 Jan-Feb;118(1):XI-XIV. Italian. PubMed PMID: 6358003. 6: Wiedey K, Renovanz HD, Maier-Lenz H. [Comparative study of therapeutic effectiveness with tolciclate and miconazole in superficial dermatophytosis and in pityriasis versicolor (author's transl)]. Mykosen. 1982 Mar;25(3):126-32. German. PubMed PMID: 7045655. 7: Gomez EC, Huntley AC, Isseroff R, Tanji J. Efficacy of tolciclate solution in patients with tinea pedis. Clin Ther. 1986;8(6):694-9. PubMed PMID: 3791364. 8: Carneri I, Monti G, Bianchi A, Castellino S, Meinardi G, Mandelli V. Tolciclate against dermatophytes. Arzneimittelforschung. 1976;26(5):769-72. PubMed PMID: 989349. 9: Battaglia A, Intini C, Perbellini A, Guglielminetti M, Viaro D, Sacchetti G. Tolciclate in the local treatment of skin candidiases: a double-blind controlled multiclinic trial versus clotrimazole. J Int Med Res. 1982;10(5):367-74. PubMed PMID: 6754510. 10: Wildfeuer A, Rozman T. [Antimycotic effect of Tolciclate]. Mykosen. 1984 Mar;27(3):142-52. German. PubMed PMID: 6727921. 11: Intini C, Battaglia A, Mangiarotti AM, Picco AM, Viaro D, Sacchetti G. Multicentre clinical study with tolciclate in the local treatment of skin mycoses in 1083 patients. Pharmatherapeutica. 1980;2(7):439-49. PubMed PMID: 7010381. 12: Mücke C. [A case of hypersensitivity to miconazole, econazole, and tolciclate (author's transl)]. Derm Beruf Umwelt. 1980;28(4):118. German. PubMed PMID: 7439033. 13: Jacob Z, Wahab S, Ghosh M, Srivastava OP. Superficial mycoses and in vitro sensitivity of dermatophytes and Candida species to tolciclate and clotrimazole. Indian J Med Res. 1981 Sep;74:365-71. PubMed PMID: 7319573. 14: Jara M, Soledad Quero M. [Treatment of superficial mycoses in children with tolciclate]. Rev Chil Pediatr. 1987 Jan-Feb;58(1):47-9. Spanish. PubMed PMID: 3441644. 15: Bianchi A, Monti G, de Carneri I. Tolciclate: further antimycotic studies. Antimicrob Agents Chemother. 1977 Sep;12(3):429-30. PubMed PMID: 907333; PubMed Central PMCID: PMC429931. 16: Polak A. Antifungal activity of four antifungal drugs in the cutaneous retention time test. Sabouraudia. 1984;22(6):501-3. PubMed PMID: 6523308. 17: Weber J, Balish E. Antifungal therapy of dermatophytosis in guinea pigs and congenitally athymic rats. Mycopathologia. 1985 Apr;90(1):47-54. PubMed PMID: 4039795. 18: Shukla PK, Khan ZA, Lal B, Agrawal PK, Srivastava OP. Clinical and experimental keratitis caused by the Colletotrichum state of Glomerella cingulata and Acrophialophora fusispora. Sabouraudia. 1983 Jun;21(2):137-47. PubMed PMID: 6683875. 19: Jacob Z, Srivastava OP. Scanning electron microscopic study of the effects of tolciclate & clotrimazole on Trichophyton rubrum. Indian J Med Res. 1983 Oct;78:518-23. PubMed PMID: 6668006. 20: Zhou X, Ko HM, Dong G. Synthesis of Bridged Cyclopentane Derivatives by Catalytic Decarbonylative Cycloaddition of Cyclobutanones and Olefins. Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13867-13871. doi: 10.1002/anie.201608158. Epub 2016 Oct 6. PubMed PMID: 27712025; PubMed Central PMCID: PMC5214575.