Silperisone, also known as RGH-5002; SILA-336, a sodium channel protein type 2 alpha channel blocker potentially for the treatment of spasticity. Silperisone is a tolperisone like organosilicon compound with centrally acting muscle relaxant properties. Silperisone might be a useful antispastic drug. However, findings in chronic animal toxicity studies led to the discontinuation of silperisone's development.
MedKoo Cat#: 328082
Name: Silperisone HCl
CAS#: 140944-30-5 (HCl)
Chemical Formula: C15H25ClFNSi
Exact Mass:
Molecular Weight: 301.91
Elemental Analysis: C, 59.68; H, 8.35; Cl, 11.74; F, 6.29; N, 4.64; Si, 9.30
The following data is based on the product molecular weight 301.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
