IUPAC/Chemical Name
(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-16-methylene-1,2,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
OKHAOBQKCCIRLO-IBVJIVQJSA-N
InChi Code
InChI=1S/C23H30O3/c1-13-10-17-18(21(4)8-6-16(25)12-19(13)21)7-9-22(5)20(17)11-14(2)23(22,26)15(3)24/h10,12,17-18,20,26H,2,6-9,11H2,1,3-5H3/t17-,18+,20+,21-,22+,23+/m1/s1
SMILES Code
CC(=O)[C@@]1(O)C(=C)C[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
354.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: McDonald MM, Agnew MK, Asa CS, Powell DM. Melengestrol acetate contraceptive implant use in colobus monkeys (Colobus guereza): Patterns through time and differences in reproductive potential and live births. Zoo Biol. 2020 Nov 25. doi: 10.1002/zoo.21581. Epub ahead of print. PMID: 33238048.
2: Gilroy ÈAM, Bartlett AJ, Gillis PL, Bendo NA, Salerno J, Hedges AM, Brown LR, Holman EAM, Stock NL, de Solla SR. Correction to: Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates. Environ Sci Pollut Res Int. 2021 Jan;28(3):3749. doi: 10.1007/s11356-020-11617-y. Erratum for: Environ Sci Pollut Res Int. 2020 Nov;27(33):41803-41815. PMID: 33216304; PMCID: PMC7852903.
3: Javed S, Atia-Tul-Wahab, Jabeen A, Zhumagaliyeva S, Abilov ZA, Atta-Ur- Rahman, Choudhary MI. Fungal mediated biotransformation of melengestrol acetate, and T-cell proliferation inhibitory activity of biotransformed compounds. Bioorg Chem. 2020 Nov;104:104313. doi: 10.1016/j.bioorg.2020.104313. Epub 2020 Sep 24. PMID: 33142425.
4: Gilroy ÈAM, Bartlett AJ, Gillis PL, Bendo NA, Salerno J, Hedges AM, Brown LR, Holman EAM, Stock NL, de Solla SR. Toxicity of the pharmaceuticals finasteride and melengestrol acetate to benthic invertebrates. Environ Sci Pollut Res Int. 2020 Nov;27(33):41803-41815. doi: 10.1007/s11356-020-10121-7. Epub 2020 Jul 22. Erratum in: Environ Sci Pollut Res Int. 2021 Jan;28(3):3749. PMID: 32696412; PMCID: PMC7679302.
5: Locke JWC, Thomas JM, Knickmeyer ER, Ellersieck MR, Yelich JV, Poock SE, Smith MF, Patterson DJ. Comparison of long-term progestin-based protocols to synchronize estrus prior to natural service or fixed-time artificial insemination in Bos indicus-influenced beef heifers. Anim Reprod Sci. 2020 Jul;218:106475. doi: 10.1016/j.anireprosci.2020.106475. Epub 2020 Apr 30. PMID: 32507258.
