MedKoo Cat#: 555212 | Name: Endoxifen E-isomer HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Endoxifen E-isomer is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

Chemical Structure

Endoxifen E-isomer HCl
Endoxifen E-isomer HCl
CAS#1197194-61-8 (E-isomer HCl)

Theoretical Analysis

MedKoo Cat#: 555212

Name: Endoxifen E-isomer HCl

CAS#: 1197194-61-8 (E-isomer HCl)

Chemical Formula: C25H28ClNO2

Exact Mass: 0.0000

Molecular Weight: 409.95

Elemental Analysis: C, 73.25; H, 6.88; Cl, 8.65; N, 3.42; O, 7.81

Price and Availability

Size Price Availability Quantity
100mg USD 950.00 2 weeks
200mg USD 1,450.00 2 weeks
500mg USD 2,150.00 2 weeks
1g USD 3,250.00 2 weeks
2g USD 5,450.00 2 weeks
5g USD 7,450.00 2 weeks
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Related CAS #
Synonym
Endoxifen E-isomer HCl;
IUPAC/Chemical Name
4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;hydrochloride
InChi Key
RPFIMPDXTABYCN-QREUMGABSA-N
InChi Code
InChI=1S/C25H27NO2.ClH/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2;/h4-16,26-27H,3,17-18H2,1-2H3;1H/b25-24+;
SMILES Code
OC1=CC=C(/C(C2=CC=C(OCCNC)C=C2)=C(C3=CC=CC=C3)/CC)C=C1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 409.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ford BM, Franks LN, Radominska-Pandya A, Prather PL. Tamoxifen Isomers and Metabolites Exhibit Distinct Affinity and Activity at Cannabinoid Receptors: Potential Scaffold for Drug Development. PLoS One. 2016 Dec 9;11(12):e0167240. doi: 10.1371/journal.pone.0167240. eCollection 2016. PubMed PMID: 27936172; PubMed Central PMCID: PMC5147891. 2: Elkins P, Coleman D, Burgess J, Gardner M, Hines J, Scott B, Kroenke M, Larson J, Lightner M, Turner G, White J, Liu P. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis. J Pharm Biomed Anal. 2014 Jan;88:174-9. doi: 10.1016/j.jpba.2013.07.010. Epub 2013 Jul 24. PubMed PMID: 24055701; PubMed Central PMCID: PMC4057282. 3: Fauq AH, Maharvi GM, Sinha D. A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). Bioorg Med Chem Lett. 2010 May 15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3. PubMed PMID: 20400308.