MedKoo Cat#: 464979 | Name: VIP152

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VIP152, also known as BAY 1251152, is a highly potent and selective CDK9 Inhibitor. VIP152 has entered clinical trials for the treatment of cancer with promising longterm, durable monotherapy activity in double-hit diffuse large B-cell lymphoma patients.

Chemical Structure

VIP152
VIP152
CAS#1610408-97-3 (S-isomer)

Theoretical Analysis

MedKoo Cat#: 464979

Name: VIP152

CAS#: 1610408-97-3 (S-isomer)

Chemical Formula: C19H18F2N4O2S

Exact Mass: 404.1119

Molecular Weight: 404.44

Elemental Analysis: C, 56.43; H, 4.49; F, 9.40; N, 13.85; O, 7.91; S, 7.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
1610358-53-6 1610358-56-9 (rotation +) 1610358-59-2 (rotation -) 1610408-96-2 (R-isomer) 1610408-97-3 (S-isomer) 1610368-60-9 (S-isomer HCl) 1610368-59-6 (R-isomer HCl)
Synonym
Enitociclib; VIP152; VIP-152; VIP 152; BAY 1251152; BAY1251152; BAY-1251152;
IUPAC/Chemical Name
(S)-((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone
InChi Key
YZCUMZWULWOUMD-NDEPHWFRSA-N
InChi Code
InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)/t28-/m0/s1
SMILES Code
FC(C=N1)=C(C2=C(OC)C=C(F)C=C2)C=C1NC3=CC(C[S@](C)(=O)=N)=CC=N3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 404.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
[1]. Luecking, et al. Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984 https://aacrjournals.org/cancerres/article/77/13_Supplement/984/622158/Abstract-984-Identification-of-potent-and-highly [2]. WO 2014076091 A1