GDP | CAS#unknown | GTP precursor

MedKoo Cat#: 464949 | Name: GDP

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Guanosine 5'-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5'-triphosphate (GTP). It has been used to study the conformations of GTPases. GDP (100 µM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.

Chemical Structure

GDP

CAS#GDP disodium hydrate

Theoretical Analysis

MedKoo Cat#: 464949

Name: GDP

CAS#: GDP disodium hydrate

Chemical Formula: C10H15N5Na2O12P2

Exact Mass: 504.9988

Molecular Weight: 505.18

Elemental Analysis: C, 23.78; H, 2.99; N, 13.86; Na, 9.10; O, 38.00; P, 12.26

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
25mg	USD 450.00	2 Weeks
50mg	USD 750.00	2 Weeks

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Related CAS #

43139-22-6 (trisodium) 7415-69-2(disodium) GDP disodium hydrate

Synonym

GDP; Guanosine 5'-diphosphate sodium salt hydrate;

IUPAC/Chemical Name

sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate hydrate

InChi Key

SYNIMEQECSCTMW-CYCLDIHTSA-L

InChi Code

InChI=1S/C10H15N5O11P2.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

SMILES Code

O=P([O-])(OC[C@@H]1[C@H]([C@H]([C@](N2C=NC3=C2NC(N)=NC3=O)(O1)[H])O)O)OP(O)([O-])=O.[Na+].[Na+].O

Appearance

Solid powder

Purity

>90% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	PBS (pH 7.2)	10.0	19.79

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 505.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ren J, Sherry AD. 31 P-MRS of healthy human brain: Measurement of guanosine diphosphate mannose at 7 T. NMR Biomed. 2021 Jun 21:e4576. doi: 10.1002/nbm.4576. Epub ahead of print. PMID: 34155714. 2: Che J, Jin Z, Yan F, You J, Xie J, Chen B, Cheng G, Zhu H, He Q, Hu Y, Yang B, Cao J, Dong X. Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis. J Med Chem. 2021 Jun 24;64(12):8621-8643. doi: 10.1021/acs.jmedchem.1c00586. Epub 2021 Jun 1. PMID: 34060833. 3: Omondi RO, Sibuyi NRS, Fadaka AO, Meyer M, Jaganyi D, Ojwach SO. Role of π-conjugation on the coordination behaviour, substitution kinetics, DNA/BSA interactions, and in vitro cytotoxicity of carboxamide palladium(II) complexes. Dalton Trans. 2021 Jun 15;50(23):8127-8143. doi: 10.1039/d1dt00412c. PMID: 34027534. 4: Ehlers AM, den Hartog Jager CF, Kardol-Hoefnagel T, Katsburg MMD, Knulst AC, Otten HG. Comparison of Two Strategies to Generate Antigen-Specific Human Monoclonal Antibodies: Which Method to Choose for Which Purpose? Front Immunol. 2021 May 4;12:660037. doi: 10.3389/fimmu.2021.660037. PMID: 34017336; PMCID: PMC8130674. 5: Ahn D, Ham D, Chung KY. The conformational transition during G protein- coupled receptor (GPCR) and G protein interaction. Curr Opin Struct Biol. 2021 May 8;69:117-123. doi: 10.1016/j.sbi.2021.03.013. Epub ahead of print. PMID: 33975155. 6: Zeng HH, Yu K, Huang J, Liu F, Zhang ZY, Chen SP, Zhang F, Guan SP, Qiu L. Ratiometric fluorescence detection of sulfide ions based on lanthanide coordination polymer using guanosine diphosphate as ligand. Colloids Surf B Biointerfaces. 2021 Aug;204:111796. doi: 10.1016/j.colsurfb.2021.111796. Epub 2021 Apr 28. PMID: 33933879. 7: Kalita J, Kapinos LE, Lim RYH. On the asymmetric partitioning of nucleocytoplasmic transport - recent insights and open questions. J Cell Sci. 2021 Apr 1;134(7):jcs240382. doi: 10.1242/jcs.240382. Epub 2021 Apr 13. PMID: 33912945. 8: Bai K, Chen X, Jiang N, Lyu Q, Li J, Luo L. Extraction and detection of guanosine 5'-diphosphate-3'-diphosphate in amino acid starvation cells of Clavibacter michiganensis. Braz J Microbiol. 2021 Apr 10. doi: 10.1007/s42770-021-00488-1. Epub ahead of print. PMID: 33837930. 9: Liu D, Mao Y, Gu X, Zhou Y, Long D. Unveiling the "invisible" druggable conformations of GDP-bound inactive Ras. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2024725118. doi: 10.1073/pnas.2024725118. PMID: 33836610; PMCID: PMC7980447.