M1G-dR | CAS#87171-83-3

MedKoo Cat#: 531402 | Name: M1G-dR

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M1G-dR, also known as 3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one, is a malondialdehyde-deoxyguanosine adduct. M1G-dR is a major DNA adduct produced by lipid peroxidation. Furthermore, the number of double bonds in polyunsaturated fatty acids was found to be the key factor in the formation of M1G-dR. The findings obtained from this study provide important information regarding the molecular pathways for M1G-dR formation by ROS, which is an essential element in understanding and evaluating the genotoxicity of a variety of ROS-inducing chemicals.

Chemical Structure

M1G-dR

CAS#87171-83-3

Theoretical Analysis

MedKoo Cat#: 531402

Name: M1G-dR

CAS#: 87171-83-3

Chemical Formula: C13H13N5O4

Exact Mass: 303.0968

Molecular Weight: 303.28

Elemental Analysis: C, 51.49; H, 4.32; N, 23.09; O, 21.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

M(1)G-deoxyribose; M1G-dR;

IUPAC/Chemical Name

3-(2'-Deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one

InChi Key

QZDHOBJINVXQCJ-ZQTLJVIJSA-N

InChi Code

InChI=1S/C13H13N5O4/c19-5-8-7(20)4-9(22-8)18-6-15-10-11(18)16-13-14-2-1-3-17(13)12(10)21/h1-3,6-9,19-20H,4-5H2/t7-,8+,9?/m0/s1

SMILES Code

O=C1N2C(N=CC=C2)=NC3=C1N=CN3C4C[C@@H]([C@@H](CO)O4)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 303.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Breast Cancer Res. 2004;6(4):R338-51. doi: 10.1186/bcr797. Epub 2004 May 7. PMID: 15217501; PMCID: PMC468635. 8: Hoberg AM, Otteneder M, Marnett LJ, Poulsen HE. Measurement of the malondialdehyde-2'-deoxyguanosine adduct in human urine by immuno-extraction and liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry. J Mass Spectrom. 2004 Jan;39(1):38-42. doi: 10.1002/jms.547. PMID: 14760611. 9: Otteneder M, Plastaras JP, Marnett LJ. Reaction of malondialdehyde-DNA adducts with hydrazines-development of a facile assay for quantification of malondialdehyde equivalents in DNA. Chem Res Toxicol. 2002 Mar;15(3):312-8. doi: 10.1021/tx010105v. PMID: 11896677. 10: Leuratti C, Watson MA, Deag EJ, Welch A, Singh R, Gottschalg E, Marnett LJ, Atkin W, Day NE, Shuker DE, Bingham SA. Detection of malondialdehyde DNA adducts in human colorectal mucosa: relationship with diet and the presence of adenomas. Cancer Epidemiol Biomarkers Prev. 2002 Mar;11(3):267-73. 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