MedKoo Cat#: 414497 | Name: Prochlorperazine mesilate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prochlorperazine mesilate is an antiemetic and an antipsychotic. Prochlorperazine mesilate has been seen to reduce the incidence and severity of vomiting and diarrhoea.

Chemical Structure

Prochlorperazine mesilate
CAS#51888-09-6 (dimesylate)

Theoretical Analysis

MedKoo Cat#: 414497

Name: Prochlorperazine mesilate

CAS#: 51888-09-6 (dimesylate)

Chemical Formula: C22H32ClN3O6S3

Exact Mass: 565.1142

Molecular Weight: 566.14

Elemental Analysis: C, 46.67; H, 5.70; Cl, 6.26; N, 7.42; O, 16.96; S, 16.99

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Related CAS #
84-02-6 (dimaleate) 58-38-8 (free base) 3450-05-3 (maleate) 3111-70-4 (mesylate) 51888-09-6 (dimesylate)
Synonym
Prochlorperazine mesilate; Novamin; Prochlorperazine dimesylate
IUPAC/Chemical Name
2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine dimethanesulphonate
InChi Key
BTOOUKJFDLARFG-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24ClN3S.2CH4O3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*1-5(2,3)4/h2-3,5-8,15H,4,9-14H2,1H3;2*1H3,(H,2,3,4)
SMILES Code
CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(Cl)C=C24)CC1.CS(=O)(O)=O.CS(=O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 566.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Morris S, Salm V, Salm A. Harm to a child caused by the off-label use of prochlorperazine maleate tablets due to the discontinuation of licensed prochlorperazine mesilate liquid in the UK. Eur J Hosp Pharm. 2024 Jun 14:ejhpharm-2023-003791. doi: 10.1136/ejhpharm-2023-003791. Epub ahead of print. PMID: 38876766. Davidson AG, Fadiran EO. Second-derivative spectrofluorometric determination of sulphoxide impurity in phenothiazine drug substances and formulation. Analyst. 1990 Jul;115(7):997-1001. doi: 10.1039/an9901500997. PMID: 2221404. Bhalla K, Jenkins CR. Intramuscular administration of 15-methyl prostaglandin F2alpha in mid-trimester termination of pregnancy. J Int Med Res. 1982;10(1):32-4. doi: 10.1177/030006058201000106. PMID: 6949846.