MedKoo Cat#: 564203 | Name: Fluoroglutamine (2S,4R)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluoroglutamine (2S,4R) is a Glutamine analog, not metabolized in the TCA cycle, but it can be incorporated into proteins and peptides. Fluoroglutamine (2S,4R) can be used as assess transporter (ASCT2) activity or protein synthesis rate.

Chemical Structure

Fluoroglutamine (2S,4R)
Fluoroglutamine (2S,4R)
CAS#238418-71-8

Theoretical Analysis

MedKoo Cat#: 564203

Name: Fluoroglutamine (2S,4R)

CAS#: 238418-71-8

Chemical Formula: C5H9FN2O3

Exact Mass: 164.0597

Molecular Weight: 164.14

Elemental Analysis: C, 36.59; H, 5.53; F, 11.57; N, 17.07; O, 29.24

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Synonym
FDG; Fluoroglutamine (2S,4R); 4-Fluoroglutamine, (4R)-; 4-L-Fluoroglutamine (2S,4R); (4R)-4-Fluoroglutamine;
IUPAC/Chemical Name
(2S,4R)-2,5-diamino-4-fluoro-5-oxopentanoic acid
InChi Key
PGEYFCBAWGQSGT-GBXIJSLDSA-N
InChi Code
InChI=1S/C5H9FN2O3/c6-2(4(8)9)1-3(7)5(10)11/h2-3H,1,7H2,(H2,8,9)(H,10,11)/t2-,3+/m1/s1
SMILES Code
NC([C@H](F)C[C@@H](C(O)=O)N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 164.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ploessl K, Wang L, Lieberman BP, Qu W, Kung HF. Comparative evaluation of 18F-labeled glutamic acid and glutamine as tumor metabolic imaging agents. J Nucl Med. 2012 Oct;53(10):1616-24. doi: 10.2967/jnumed.111.101279. Epub 2012 Aug 30. PubMed PMID: 22935578. 2: Cooper AJ, Krasnikov BF, Pinto JT, Kung HF, Li J, Ploessl K. Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate. Comp Biochem Physiol B Biochem Mol Biol. 2012 Sep;163(1):108-20. doi: 10.1016/j.cbpb.2012.05.010. Epub 2012 May 19. PubMed PMID: 22613816; PubMed Central PMCID: PMC3389287.