Related CAS #
536-21-0 (free base)
4779-94-6 (HCl)
1420-80-0 (S-isomer)
5596-07-6 (R-isomer)
Synonym
Norfenefrine Free Base; BRN1211018; BRN-1211018; BRN 1211018; Norenol
IUPAC/Chemical Name
alpha-(Aminomethyl)-m-hydroxybenzyl alcohol
InChi Key
LRCXRAABFLIVAI-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H11NO2/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4,8,10-11H,5,9H2
SMILES Code
OC1=CC(C(O)CN)=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
153.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Magometschnigg D, Stengele E. Norfenefrine: haemodynamic effects in healthy volunteers at rest and during orthostasis. Eur J Clin Pharmacol. 1983;25(2):167-71. doi: 10.1007/BF00543786. PMID: 6628499.
2: Lose G, Rix P, Diernaes E, Alexander N. Norfenefrine in the treatment of female stress incontinence. A double-blind controlled trial. Urol Int. 1988;43(1):11-5. doi: 10.1159/000281294. PMID: 3287737.
3: Reimann W. Evidence for neuronal uptake and release of norfenefrine and evaluation of its alpha-agonistic effects in the rabbit pulmonary artery. Arzneimittelforschung. 1984;34(5):575-8. PMID: 6147146.
4: Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. 2002 Apr;301(1):229-33. doi: 10.1124/jpet.301.1.229. PMID: 11907178.
5: Jørgensen L, Lose G, Alexander N. Acute effect of norfenefrine on the urethral pressure profile in females with genuine stress incontinence. Urol Int. 1991;46(2):176-9. doi: 10.1159/000282127. PMID: 2053226.
6: Schumann U, Jenkinson CP, Alt A, Zügel M, Steinacker JM, Flechtner-Mors M. Sympathetic nervous system activity and anti-lipolytic response to iv-glucose load in subcutaneous adipose tissue of obese and obese type 2 diabetic subjects. PLoS One. 2017 Mar 27;12(3):e0173803. doi: 10.1371/journal.pone.0173803. PMID: 28346464; PMCID: PMC5367786.
7: Hengstmann JH, Goronzy J. Enterale Resorption und Bioverfügbarkeit von Norfenefrin [Enteral resorption and bioavailability of norfenefrine]. Arzneimittelforschung. 1980;30(12):2164-7. German. PMID: 7194079.
8: Flechtner-Mors M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH. Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor in human obesity. Obes Res. 2004 Apr;12(4):612-20. doi: 10.1038/oby.2004.70. PMID: 15090628.
9: Schmitt WM, Kindermann W, Stengele E, André W. Der Einfluss von Norfenefrin auf Kreislauf, Plasmakatecholamine und Stoffwechsel in Ruhe und während Belastung [The effect of norfenefrine on circulation, plasma catecholamines and metabolism at rest and during exertion]. Z Kardiol. 1983 Jun;72(6):321-6. German. PMID: 6351455.
10: Laven R, Schäfer EA. Freisetzung von Norfenefrin-HCl aus Depotpräparaten in einem In-vitro-Lösemodell. Rechnerische Simulation von Wirkstoffprofilen mit Hilfe pharmakokinetischer Parameter und Vergleich mit In-vivo-Wirkungsverläufen [Release of norfenefrine from sustained-release formulations by an in vitro dissolution model. Simulation of "drug levels" by calculation using pharmacokinetical constants and comparison with in vivo course of action (author's transl)]. Arzneimittelforschung. 1981;31(2):353-6. German. PMID: 7194653.
