Norfenefrine HCl | CAS#4779-94-6| Adrenergic Agonist.

MedKoo Cat#: 592600 | Name: Norfenefrine HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norfenefrine is an Adrenergic Agonist. It is used in the treatment of female stress incontinence.

Chemical Structure

Norfenefrine HCl

CAS#4779-94-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 592600

Name: Norfenefrine HCl

CAS#: 4779-94-6 (HCl)

Chemical Formula: C8H12ClNO2

Exact Mass: 153.0790

Molecular Weight: 189.64

Elemental Analysis: C, 50.67; H, 6.38; Cl, 18.69; N, 7.39; O, 16.87

Price and Availability

Size	Price	Availability
1g	USD 150.00	2 Weeks
10g	USD 250.00	2 Weeks
25g	USD 550.00	2 Weeks
50g	USD 850.00	2 Weeks
100g	USD 1,250.00	2 Weeks

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Related CAS #

536-21-0 (free base) 4779-94-6 (HCl) 1420-80-0 (S-isomer) 5596-07-6 (R-isomer)

Synonym

Esbuphon; m-Octopamine hydrochloride; Molycor-R hydrochloride; Norfenefrine HCl; Norfenefrine Hydrochloride; Norphenephrine hydrochloride; Norphenylephrine hydrochloride; NSC 100733; NSC 297582; WIN 5501; WV 569; Zondel;

IUPAC/Chemical Name

Benzenemethanol, alpha-(aminomethyl)-3-hydroxy-, hydrochloride (9CI)

InChi Key

OWMFSWZUAWKDRR-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H11NO2.ClH/c9-5-8(11)6-2-1-3-7(10)4-6;/h1-4,8,10-11H,5,9H2;1H

SMILES Code

OC(CN)C1=CC=CC(O)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Norfenefrine is an Adrenergic Agonist.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 189.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Magometschnigg D, Stengele E. Norfenefrine: haemodynamic effects in healthy volunteers at rest and during orthostasis. Eur J Clin Pharmacol. 1983;25(2):167-71. PubMed PMID: 6628499. 2: Lose G, Rix P, Diernaes E, Alexander N. Norfenefrine in the treatment of female stress incontinence. A double-blind controlled trial. Urol Int. 1988;43(1):11-5. PubMed PMID: 3287737. 3: Hengstmann JH. [Therapy of idiopathic orthostatic hypotension with norfenefrine]. Med Klin (Munich). 1986 Oct 17;81(21):681-4. German. PubMed PMID: 3796505. 4: Reimann W. Evidence for neuronal uptake and release of norfenefrine and evaluation of its alpha-agonistic effects in the rabbit pulmonary artery. Arzneimittelforschung. 1984;34(5):575-8. PubMed PMID: 6147146. 5: Hengstmann JH, Goronzy J. [Enteral resorption and bioavailability of norfenefrine]. Arzneimittelforschung. 1980;30(12):2164-7. German. PubMed PMID: 7194079. 6: Jørgensen L, Lose G, Alexander N. Acute effect of norfenefrine on the urethral pressure profile in females with genuine stress incontinence. Urol Int. 1991;46(2):176-9. PubMed PMID: 2053226. 7: Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. 2002 Apr;301(1):229-33. PubMed PMID: 11907178. 8: Lose G, Lindholm P. Clinical and urodynamic effects of norfenefrine in women with stress incontinence. Urol Int. 1984;39(5):298-302. PubMed PMID: 6150569. 9: Boldt J, Müller H, Börner U, Kling D, Moosdorf R, Hempelmann G. [Isolated modification of the vascular system by vasopressor agents (akrinor, etilefrin, ephedrine, norfenefrine, amezinium) during extracorporeal circulation in man]. Anaesthesist. 1986 Feb;35(2):93-8. German. PubMed PMID: 2870661. 10: Diernaes E, Rix P, Sørensen T, Alexander N. Norfenefrine in the treatment of female urinary stress incontinence assessed by one-hour pad weighing test. Urol Int. 1989;44(1):28-31. PubMed PMID: 2568712. 11: Laven R, Schäfer EA. [Release of norfenefrine from sustained-release formulations by an in vitro dissolution model. Simulation of "drug levels" by calculation using pharmacokinetical constants and comparison with in vivo course of action (author's transl)]. Arzneimittelforschung. 1981;31(2):353-6. German. PubMed PMID: 7194653. 12: Wilsmann K, Neugebauer G, Kessel R, Lang E. Cardiovascular effects of amezinium in humans during passive upright tilt in comparison with norfenefrine and dihydroergotamine. Arzneimittelforschung. 1981;31(9a):1647-52. PubMed PMID: 7197979. 13: [Hypotension therapy with norfenefrine--oral administration also dependably effective]. Fortschr Med. 1983 Aug 11;101(30):1386. German. PubMed PMID: 6618400. 14: Hinder F, Stubbe HD, Van Aken H, Baba HA, Jahn UR, Brodner G, August C, Erren M, Booke M. Early multiple organ failure after recurrent endotoxemia in the presence of vasoconstrictor-masked hypovolemia. Crit Care Med. 2003 Mar;31(3):903-9. PubMed PMID: 12627003. 15: Flechtner-Mors M, Jenkinson CP, Alt A, Biesalski HK, Adler G, Ditschuneit HH. Sympathetic regulation of glucose uptake by the alpha1-adrenoceptor in human obesity. Obes Res. 2004 Apr;12(4):612-20. PubMed PMID: 15090628. 16: Klosa W, Wilhelm C, Schillinger H, Hillemanns HG. [Therapy of hypotension in pregnancy using norfenefrine hydrochloride with special reference to the effects on fetal circulation--initial observations]. Z Geburtshilfe Perinatol. 1992 Jan-Feb;196(1):21-5. German. PubMed PMID: 1549916. 17: Pittner H. Vasoconstrictor effects of midodrine, ST 1059, noradrenaline, etilefrine and norfenefrine on isolated dog femoral arteries and veins. Gen Pharmacol. 1983;14(1):107-9. PubMed PMID: 6186570. 18: Schmitt WM, Kindermann W, Stengele E, André W. [The effect of norfenefrine on circulation, plasma catecholamines and metabolism at rest and during exertion]. Z Kardiol. 1983 Jun;72(6):321-6. German. PubMed PMID: 6351455. 19: Baba HA, Wohlschlaeger J, Stubbe HD, Grabellus F, Aken HV, Schmitz KJ, Otterbach F, Schmid KW, August C, Levkau B, Hinder F. Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheep. Intensive Care Med. 2004 Jul;30(7):1405-13. Epub 2004 Feb 24. PubMed PMID: 14985962. 20: Gao Y, Shen Z, Wang H, Dai Z, Lin B. Chiral separations on multichannel microfluidic chips. Electrophoresis. 2005 Dec;26(24):4774-9. PubMed PMID: 16278920.